Belvederi Fabio, Leggeri Simone, Urbani Andrea, Baroni Silvia
Department of Basic Biotechnological Sciences, Intensive Care and Perioperative Clinics, Catholic University of Sacred Heart, 00168 Rome, Italy.
Department of Basic Biotechnological Sciences, Intensive Care and Perioperative Clinics, Catholic University of Sacred Heart, 00168 Rome, Italy; Unit of Chemistry, Biochemistry and Molecular Biology, "A. Gemelli" Hospital Foundation IRCCS, Largo A. Gemelli, 8, 00168 Rome, Italy.
Clin Chim Acta. 2025 Jun 1;573:120303. doi: 10.1016/j.cca.2025.120303. Epub 2025 Apr 11.
The urokinase-type plasminogen activator receptor (uPAR) system, which includes protease, receptor and inhibitors, is essential for key cellular functions like immune activation, cell migration, and tissue remodeling. Soluble uPAR (suPAR), released into circulation, serves as a valuable biomarker for systemic inflammation and immune activation. Elevated suPAR levels are associated with disease severity in conditions such as infections, sepsis, cardiovascular diseases, renal injury, cancer, and autoimmune diseases providing prognostic value especially in acute settings. Recent advancements in diagnostic methods, have enhanced the accuracy of suPAR measurement in serum and plasma. New rapid tests, such as suPARnostic Quick Triage, as well as turbidimetric assays, further expand its clinical applicability. In this review, we discuss the suPAR biomarker, focusing on its biochemical structure, biological functions, measurement methods and areas of clinical interest in different fields of medicine.
尿激酶型纤溶酶原激活物受体（uPAR）系统，包括蛋白酶、受体和抑制剂，对于免疫激活、细胞迁移和组织重塑等关键细胞功能至关重要。释放到循环系统中的可溶性uPAR（suPAR）是全身炎症和免疫激活的重要生物标志物。suPAR水平升高与感染、败血症、心血管疾病、肾损伤、癌症和自身免疫性疾病等病症的疾病严重程度相关，尤其在急性情况下具有预后价值。诊断方法的最新进展提高了血清和血浆中suPAR测量的准确性。新的快速检测方法，如suPARnostic快速分诊检测，以及比浊法检测，进一步扩大了其临床应用范围。在本综述中，我们讨论suPAR生物标志物，重点关注其生化结构、生物学功能、测量方法以及在不同医学领域的临床应用领域。
