Al Qurashi Mansour
Department of Paediatrics, Ministry of National Guard Health Affairs (MNGHA), King Abdulaziz Medical City, Jeddah, Kingdom of Saudi Arabia.
College of Medicine, King Saud Bin Abdul Aziz University for Health Sciences (KSAU-HS), King Abdullah International Medical Research Centre (KAIMRC), Ministry of National Guard Health Affairs (MNGHA), King Abdulaziz Medical City, Jeddah, Saudi Arabia.
J Neonatal Perinatal Med. 2025 Mar;18(2):137-141. doi: 10.1177/19345798241310150. Epub 2025 Feb 19.
BackgroundPreterm infants with a birth weight of less than 1000 grams (g), extreme low birth weight (ELBW) account for approximately 0.6% of all live births. Despite their small proportion, they contribute significantly to neonatal deaths, short-term morbidities, and long-term sequalae among survivors. This study aims to evaluate the survival trends of ELBW infants over the study period and the impact of gender on survival odds.MethodsThis retrospective cohort study involved ELBW infants admitted to our neonatal intensive care unit over 16 years (2008-2023). We examined their survival trends in context with their gender to analyze impact on survival odds.ResultsOut of 336 infants who met the inclusion criteria, 175 were males (52.1%) and 161 (47.9%) were females. The mean birth weight for males was 780 g (SD = 134 g), and 770 g (SD = 132) for females, while the mean gestational age (GA) was 26.2 weeks (SD = 2.14 week) for males and 26.6 weeks (SD = 2.18 week) for females. Female ELBW infants had a higher survival rate of 78.9% compared to 68.6% for males, with an odds ratio (OR) of 1.712 ( value = 0.017). The survival advantage for females was more evident among birth weight of less than (<) 750 g (62% vs 44%) with an OR of 2.06 ( value = 0.023).ConclusionThis study demonstrated that female ELBW infants have a higher survival rate than males, particularly with birth weight under 750 g.
背景
出生体重低于1000克的早产儿，即极低出生体重儿（ELBW），约占所有活产婴儿的0.6%。尽管他们所占比例较小，但对新生儿死亡、短期发病率以及幸存者的长期后遗症有重大影响。本研究旨在评估研究期间极低出生体重儿的生存趋势以及性别对生存几率的影响。
方法
这项回顾性队列研究纳入了在16年期间（2008 - 2023年）入住我们新生儿重症监护病房的极低出生体重儿。我们结合性别来研究他们的生存趋势，以分析对生存几率的影响。
结果
在符合纳入标准的336名婴儿中，175名是男性（52.1%），161名（47.9%）是女性。男性的平均出生体重为780克（标准差 = 134克），女性为770克（标准差 = 132克），而男性的平均胎龄（GA）为26.2周（标准差 = 2.14周），女性为26.6周（标准差 = 2.18周）。女性极低出生体重儿的生存率较高，为78.9%，而男性为68.6%，优势比（OR）为1.712（P值 = 0.017）。在出生体重低于750克的婴儿中，女性的生存优势更为明显（62%对44%），OR为2.06（P值 = 0.023）。
结论
本研究表明，女性极低出生体重儿的生存率高于男性，尤其是出生体重低于750克的情况。
