Kishida Yuya, Sakaguchi Masahiro, Kunishige Tomoyuki, Takeyoshi Atsushi, Tokura Taichiro, Inai Kazuki, Kinoshita Ryosuke, Ibaraki Toshio, Yamanaka Satoshi, Asayama Toshio, Yui Shunsuke, Wakita Satoshi, Yamaguchi Hiroki
Department of Hematology, Nippon Medical School, Japan.
Department of Ophthalmology, Nippon Medical School, Japan.
Intern Med. 2025 Apr 12. doi: 10.2169/internalmedicine.4657-24.
We report the case of a 61-year-old man with chronic myelomonocytic leukemia, who underwent unrelated peripheral blood stem cell transplantation. Fusariosis was suspected prior to identification of the fungal species, and voriconazole and liposomal amphotericin B combination therapy were administered. The patient developed fusarium-related endophthalmitis, accompanied by eye pain. Despite vitrectomy, the endophthalmitis was poorly controlled, and the left eye was enucleated. No recurrence of fusariosis was observed until death following multiple-organ failure due to steroid-resistant graft-versus-host disease.
我们报告了一例61岁慢性粒单核细胞白血病男性患者，其接受了非亲缘外周血干细胞移植。在鉴定出真菌种类之前怀疑为镰刀菌病，并给予伏立康唑和脂质体两性霉素B联合治疗。该患者发生了与镰刀菌相关的眼内炎，并伴有眼痛。尽管进行了玻璃体切除术，但眼内炎控制不佳，左眼被摘除。在因类固醇难治性移植物抗宿主病导致多器官衰竭死亡之前，未观察到镰刀菌病复发。
