Wang Caimu, Zhou Yiping, Zhong Chao, Shan Hui, Wang Ping, Ge Zisheng, Fan Yushi, Zhang Xinyun, Zhang Kai, Wang Yesong, Cui Wei, Du Linlin, Chen Qijiang, Zhang Gensheng
Department of Critical Care Medicine, Ninghai First Hospital, Zhejiang, 315600, China.
Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.
Sci Rep. 2025 Apr 13;15(1):12732. doi: 10.1038/s41598-025-97024-0.
This study evaluated the predictive value of cell index (CI), cerebrospinal fluid procalcitonin (CSF PCT), and cerebrospinal fluid interleukin-6 (CSF IL-6) for detecting intracranial infection after neurosurgery. A two-center, prospective study analyzed CSF samples from ICU patients suspected of having intracranial infection following neurosurgery from January 2020 to June 2023. Patients with infection had longer operation times and longer stays in the ICU. The AUCs for single biomarkers ranged from 0.829 to 0.860, with the highest AUC of 0.938 observed for the combined biomarkers CI + CSF PCT + CSF IL-6. CI was most effective in patients with elevated CSF RBC counts, and PCT was most effective for detecting Gram-negative infections. The combined use of these biomarkers enhances early diagnosis of intracranial infection after neurosurgery and warrants further study.
本研究评估了细胞指数（CI）、脑脊液降钙素原（CSF PCT）和脑脊液白细胞介素-6（CSF IL-6）在检测神经外科手术后颅内感染方面的预测价值。一项两中心前瞻性研究分析了2020年1月至2023年6月期间重症监护病房（ICU）疑似神经外科手术后颅内感染患者的脑脊液样本。感染患者的手术时间更长，在ICU的停留时间也更长。单一生物标志物的曲线下面积（AUC）范围为0.829至0.860，联合生物标志物CI + CSF PCT + CSF IL-6的AUC最高，为0.938。CI在脑脊液红细胞计数升高的患者中最有效，PCT在检测革兰氏阴性感染方面最有效。这些生物标志物的联合使用可提高神经外科手术后颅内感染的早期诊断率，值得进一步研究。
