Andhare Pradhnesh, Laidlaw Brian J
Division of Allergy and Immunology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Immunol Cell Biol. 2025 May;103(5):415-417. doi: 10.1111/imcb.70022. Epub 2025 Apr 13.
In this Research Highlight, we discuss two recently published studies that show that germinal center B cells undergoing multiple rounds of cell division strongly suppress their rate of somatic hypermutation. These studies provide an explanation for how high-affinity germinal center B cells avoid deleterious mutations that could impair antibody affinity maturation.
