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髓内穿针固定术及重组人骨形态发生蛋白-2对犬尺骨近端截骨术后并发症的影响

Impact of intramedullary pinning and recombinant human bone morphogenetic protein-2 on postoperative complications after proximal ulnar osteotomy in dogs.

作者信息

Danielski Alan, Wilson Holly A, Solano Miguel A

机构信息

The Ralph Veterinary Referral Center, Marlow, UK.

出版信息

Vet Surg. 2025 Aug;54(6):1094-1100. doi: 10.1111/vsu.14260. Epub 2025 Apr 14.

DOI:10.1111/vsu.14260
PMID:40223479
Abstract

OBJECTIVE

To evaluate the complication rate following proximal ulnar osteotomy (PUO) performed in conjunction with the use of an intramedullary pin and bone morphogenetic proteins in dogs, and to assess the impact of these variables on surgical outcomes.

STUDY DESIGN

Retrospective study.

SAMPLE POPULATION

A total of 93 limbs (74 dogs).

METHODS

Medical records and radiographs of dogs that underwent oblique PUO with intramedullary pin and recombinant human bone morphogenetic protein-2 (rhBMP-2) application between January 2022 and June 2024 were reviewed. Data collected included breed, age, weight, surgical indication, and postoperative complications, classified as minor or major. Radiographic assessments were performed to evaluate bone healing 6 weeks after surgery.

RESULTS

Follow-up examination and radiographs were performed in all cases at a mean time of 6 ± 1.1 weeks after surgery. The overall complication rate was 7.4%, with major complications, primarily surgical site infections (4 out of 5 cases), occurring in five of 93 limbs (5.3%). Minor complications, including seroma and delayed union, were observed in two of 93 limbs (2.1%). No cases of non-union were documented, with 92/93 limbs achieving radiographic healing within the expected timeframe. A total of 48 (64.8%) of the dogs treated were chondrodystrophic breeds, historically considered at high risk of complications.

CONCLUSION

The combined use of an intramedullary pin and rhBMP-2 was associated with low complication rates and enhanced bone healing, even in chondrodystrophic breeds.

CLINICAL SIGNIFICANCE

This study supports the use of an intramedullary pin and rhBMP-2 in PUO as a safe and effective strategy to minimize complications, including in high-risk breeds.

摘要

目的

评估犬尺骨近端截骨术(PUO)联合使用髓内针和骨形态发生蛋白后的并发症发生率,并评估这些变量对手术结果的影响。

研究设计

回顾性研究。

样本群体

共93条肢体(74只犬)。

方法

回顾了2022年1月至2024年6月间接受斜行PUO并应用髓内针和重组人骨形态发生蛋白-2(rhBMP-2)的犬的病历和X光片。收集的数据包括品种、年龄、体重、手术指征和术后并发症,分为轻微或严重并发症。术后6周进行X光评估以评估骨愈合情况。

结果

所有病例均在术后平均6±1.1周进行了随访检查和X光片拍摄。总体并发症发生率为7.4%,93条肢体中有5条(5.3%)出现严重并发症,主要为手术部位感染(5例中的4例)。93条肢体中有2条(2.1%)出现轻微并发症,包括血清肿和延迟愈合。未记录到骨不连病例,93条肢体中有92条在预期时间内实现了X光愈合。接受治疗的犬中共有48只(64.8%)为软骨发育不良品种,历来被认为并发症风险较高。

结论

即使在软骨发育不良品种中,联合使用髓内针和rhBMP-2也与低并发症发生率和增强的骨愈合相关。

临床意义

本研究支持在PUO中使用髓内针和rhBMP-2作为一种安全有效的策略,以尽量减少并发症,包括在高风险品种中。

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