Sze Alyssa H, Pola Akhil S, Smith Amanda G, Vora Jay, Greenage Michael P
Sze, MS, Department of Psychiatry and Behavioral Medicine, Carilion Clinic-Virginia Tech Carilion School of Medicine, Roanoke, VA, USA.
Pola, MBBS, Department of Psychiatry and Behavioral Medicine, Carilion Clinic-Virginia Tech Carilion School of Medicine, Roanoke, VA, USA.
Psychopharmacol Bull. 2025 Apr 8;55(3):56-59.
Clozapine is an atypical antipsychotic and is the drug of choice for treatment-resistant schizophrenia. Unlike other atypical antipsychotics which are known to occasionally cause symptoms of mania or hypomania, clozapine has been shown to be effective at symptom reduction during manic episodes in treatment-resistant bipolar disorder and is generally well tolerated in those severe mood disorders. To our knowledge, there is only one other reported case of potential clozapine-induced mania. In this case report and review, we present a 47-year-old caucasian male with a well-established history of schizophrenia who was voluntarily admitted to an inpatient psychiatric unit for paranoia and auditory hallucinations. The patient had trialed multiple antipsychotics prior to the current hospitalization, with the exception of clozapine. To our knowledge, this is the second case report of manic-like symptoms that may be secondary to clozapine.
氯氮平是一种非典型抗精神病药物，是难治性精神分裂症的首选药物。与其他已知偶尔会引起躁狂或轻躁狂症状的非典型抗精神病药物不同，氯氮平已被证明在难治性双相情感障碍的躁狂发作期间对减轻症状有效，并且在那些严重情绪障碍患者中通常耐受性良好。据我们所知，仅有另外一例关于氯氮平诱发躁狂的报道。在本病例报告及综述中，我们介绍了一名47岁的白种男性，他有明确的精神分裂症病史，因妄想和幻听自愿入住住院精神科病房。该患者在此次住院前曾试用过多种抗精神病药物，但未使用过氯氮平。据我们所知，这是第二例可能继发于氯氮平的类躁狂症状的病例报告。
