睡眠时间与中风风险之间的联系。

The link between sleep duration and stroke risk.

作者信息

Cheng Yu, Ding Yuchuan, Elmadhoun Ahmed, Ji Xunming, Geng Xiaokun

机构信息

Luhe Institute of Neuroscience, Capital Medical University, Beijing, China.

Department of Neurology, Beijing Luhe Hospital, Capital Medical University, Beijing, China.

出版信息

Brain Circ. 2025 Mar 21;11(1):1-8. doi: 10.4103/bc.bc_7_24. eCollection 2025 Jan-Mar.

Abstract

In this review paper, we explore the complex relationship between sleep duration and stroke risk, outlining the association of both insufficient sleep and excessive sleep with an increased risk of cerebrovascular diseases. We explore a U-shaped relationship between sleep duration and cardiovascular outcomes, including stroke. Our review explores findings from cohort studies, meta-analyses, and Mendelian randomization studies, highlighting the nuanced findings and identifying gaps in the current literature. We discussed the direct and indirect effects of sleep duration on stroke risk, considering factors such as atherosclerosis, atrial fibrillation, hypertension, and hyperlipidemia. We also discuss the methodological challenges inherent in current studies, such as the reliance on self-reported sleep measures and the need for more objective and comprehensive assessments. The paper emphasizes the importance of recognizing individual variations in optimal sleep duration and the potential confounding effects of sleep quality and other sleep-related disorders on stroke risk. Furthermore, we explore the potential mechanisms by which sleep duration may influence endothelial function, oxidative stress, and vascular compliance, suggesting areas for future investigation. The paper makes a compelling case for the inclusion of sleep duration as a key factor in stroke prevention strategies, recommending that healthcare professionals proactively assess and manage sleep patterns to mitigate stroke risk.

摘要

在这篇综述论文中,我们探讨了睡眠时间与中风风险之间的复杂关系,概述了睡眠不足和睡眠过多与脑血管疾病风险增加之间的关联。我们探究了睡眠时间与包括中风在内的心血管结局之间的U型关系。我们的综述探讨了队列研究、荟萃分析和孟德尔随机化研究的结果,突出了细微的研究结果并找出当前文献中的空白。我们讨论了睡眠时间对中风风险的直接和间接影响,考虑了动脉粥样硬化、心房颤动、高血压和高脂血症等因素。我们还讨论了当前研究中固有的方法学挑战,例如依赖自我报告的睡眠测量方法以及需要更客观和全面的评估。该论文强调了认识到最佳睡眠时间的个体差异以及睡眠质量和其他与睡眠相关的疾病对中风风险的潜在混杂影响的重要性。此外,我们探究了睡眠时间可能影响内皮功能、氧化应激和血管顺应性的潜在机制,提出了未来研究的方向。该论文有力地论证了将睡眠时间纳入中风预防策略的关键因素,建议医疗保健专业人员积极评估和管理睡眠模式以降低中风风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f3e/11984815/ba6218326798/BC-11-1-g001.jpg

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