Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China; School of Public Health, Southwest Medical University, Luzhou, Sichuan, China.
Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Sleep Med Rev. 2024 Oct;77:101965. doi: 10.1016/j.smrv.2024.101965. Epub 2024 May 31.
Two researchers independently assessed studies published up to February 5, 2023, across PubMed, Web of Science, Embase, and Cochrane Library, to investigate the associations of sleep traits with cardiometabolic risk factors, as well as with cardiovascular diseases. Fourteen systematic reviews consisting of 23 meta-analyses, and 11 Mendelian randomization (MR) studies were included in this study. Short sleep duration was associated with a higher risk of obesity, type 2 diabetes (T2D), hypertension, stroke, and coronary heart disease (CHD) in observational studies, while a causal role was only demonstrated in obesity, hypertension, and CHD by MR. Similarly, long sleep duration showed connections with a higher risk of obesity, T2D, hypertension, stroke, and CHD in observational studies, none was supported by MR analysis. Both observational and MR studies indicated heightened risks of hypertension, stroke, and CHD in relation to insomnia. Napping was linked to elevated risks of T2D and CHD in observational studies, with MR analysis confirming a causal role in T2D. Additionally, snoring was correlated with increased risks of stroke and CHD in both observational and MR studies. This work consolidates existing evidence on a causal relationship between sleep characteristics and cardiometabolic risk factors, as well as cardiovascular diseases.
两位研究人员独立评估了截至 2023 年 2 月 5 日在 PubMed、Web of Science、Embase 和 Cochrane Library 上发表的研究，以调查睡眠特征与心血管代谢风险因素以及心血管疾病的关联。本研究共纳入了 14 项系统评价，其中包含 23 项荟萃分析和 11 项孟德尔随机研究。观察性研究表明，睡眠时间短与肥胖、2 型糖尿病（T2D）、高血压、中风和冠心病（CHD）的风险增加有关，但孟德尔随机研究仅证实了肥胖、高血压和 CHD 与睡眠时间短有关。同样，长睡眠时间与肥胖、T2D、高血压、中风和 CHD 的风险增加有关，但孟德尔随机研究没有支持这一结果。观察性和孟德尔随机研究均表明，失眠与高血压、中风和 CHD 的风险增加有关。观察性研究表明，午睡与 T2D 和 CHD 的风险增加有关，孟德尔随机研究证实了 T2D 中的因果关系。此外，观察性和孟德尔随机研究均表明，打鼾与中风和 CHD 的风险增加有关。这项工作整合了现有证据，表明睡眠特征与心血管代谢风险因素以及心血管疾病之间存在因果关系。
