Karakoç-Parlayan Hanife Nur, Bulut Dilek, Haykır-Solay Aslı, Kuzi Semanur, Arıkan Tuğba, Şencan İrfan
Department of Infectious Diseases and Clinical Microbiology, Karadeniz Technical University School of Medicine, Trabzon, Türkiye.
Department of Infectious Diseases and Clinical Microbiology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Türkiye.
Infect Dis Clin Microbiol. 2025 Mar 27;7(1):47-57. doi: 10.36519/idcm.2025.458. eCollection 2025 Mar.
The increasing proportion of the elderly population necessitates the development of strategies for managing infections encountered by this group. We aimed to examine the distribution of bacterial infections, their clinical presentations, treatments used, and in-hospital mortality rates among elderly patients.
We examined a cohort aged 65-79 (Group 1) and aged 80 and above (Group 2) with bacterial infections. Demographic characteristics, underlying conditions, clinical/laboratory findings, and mortality rates of the cases were compared.
The study included 177 patients, of which 44.6% were female, and the mean age was 76.0 ± 8.8 years. Group 2 included 36.7% of the study population with a higher incidence of sepsis and urinary system infections (=0.038 and =0.037, respectively). On the other hand, skin and soft tissue infections (42%) emerged as the predominant cause of hospital admissions in Group 1 (<0.001). Fatigue and dysuria were more frequent in Group 2 (=0.008 and =0.044, respectively), and erythema was more common in Group 1 (=0.012). Hypertension (58.2%) was the most frequently observed comorbidity. Neurological diseases/dementia were more common in Group 2 than in Group 1 (=0.036). Also, a delayed procalcitonin response to antibiotics was noted in Group 2 (=0.006). Beta-lactam/beta-lactamase inhibitors were the most frequently used antibiotics, and cephalosporin antibiotics were preferred to a greater extent in Group 2 (=0.02).
The increased rates of urinary tract infections and sepsis in individuals over 80 underscores the need for vigilant clinical oversight. Effectively managing underlying conditions can reduce the incidence of some infections in vulnerable groups.
老年人口比例的不断增加使得制定针对该群体所遇感染的管理策略成为必要。我们旨在研究老年患者中细菌感染的分布情况、临床表现、所用治疗方法及院内死亡率。
我们研究了年龄在65 - 79岁（第1组）和80岁及以上（第2组）的细菌感染队列。比较了病例的人口统计学特征、基础疾病、临床/实验室检查结果及死亡率。
该研究纳入了177例患者，其中44.6%为女性，平均年龄为76.0±8.8岁。第2组占研究人群的36.7%，败血症和泌尿系统感染的发生率较高（分别为=0.038和=0.037）。另一方面，皮肤和软组织感染（42%）是第1组住院的主要原因（<0.001）。第2组疲劳和排尿困难更为常见（分别为=0.008和=0.044），第1组红斑更为常见（=0.012）。高血压（58.2%）是最常见的合并症。神经疾病/痴呆在第2组比第1组更常见（=0.036）。此外，第2组降钙素原对抗生素的反应延迟（=0.006）。β-内酰胺/β-内酰胺酶抑制剂是最常用的抗生素，第2组更倾向于使用头孢菌素类抗生素（=0.02）。
80岁以上人群尿路感染和败血症发生率的增加凸显了临床密切监测的必要性。有效管理基础疾病可降低弱势群体中某些感染的发生率。
