2023年中国23个PLAD地区健康体检女性高危型人乳头瘤病毒感染与宫颈细胞学的关联
Association Between High-Risk Human Papillomavirus Infection and Cervical Cytology in Health Check-Up Women - 23 PLADs, China, 2023.
作者信息
Gao Di, Zhao Gengli, Wang Xueyin, Juan Juan, Shi Yupeng, Xu Taoye, Wang Yue, Wang Linhong, Zhang Xiaosong
机构信息
Department of Obstetrics and Gynecology and Reproductive Medicine, Peking University First Hospital, Beijing, China.
Hangzhou Dian Medical Laboratory Center, Hangzhou City, Zhejiang Province, China.
出版信息
China CDC Wkly. 2025 Mar 7;7(10):327-333. doi: 10.46234/ccdcw2025.053.
WHAT IS ALREADY KNOWN ABOUT THIS TOPIC?: Previous studies have documented the prevalence and distribution of human papillomaviruses (HPV) infection. However, there is limited current nationwide data on HPV distribution across different cytological conditions in recent years.
WHAT IS ADDED BY THIS REPORT?: This nationwide, cross-sectional study reveals that detection rates of HR-HPV infection and abnormal cytology among women undergoing health check-ups remain relatively high in China. Among women with abnormal cervical cytology, HPV-16 was the most prevalent HR-HPV genotype, followed by HPV-58 and HPV-52.
WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE?: These findings, based on a large population sample across China, provide critical insights into current cervical cancer screening outcomes and can inform the development of HPV genotype-specific vaccination and screening strategies to reduce cervical cancer burden.
关于该主题已知的信息有哪些？：既往研究记录了人乳头瘤病毒（HPV）感染的患病率和分布情况。然而，目前全国范围内关于近年来不同细胞学状况下HPV分布的数据有限。
本报告补充了哪些内容？：这项全国性横断面研究表明，在中国接受健康检查的女性中，高危型HPV感染和细胞学异常的检出率仍然相对较高。在宫颈细胞学异常的女性中，HPV-16是最常见的高危型HPV基因型，其次是HPV-58和HPV-52。
对公共卫生实践有何启示？：这些基于中国大量人群样本的研究结果，为当前宫颈癌筛查结果提供了关键见解，并可为制定特定HPV基因型的疫苗接种和筛查策略提供参考，以减轻宫颈癌负担。
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