Chen Weihong, Sun Qin, Shen Xinru, Zhu Jinlong, Wang Zhipeng, Peng Yan
Department of Endocrinology, Ma'anshan People's Hospital Ma'anshan 243000, Anhui, China.
Am J Transl Res. 2025 Mar 15;17(3):2057-2066. doi: 10.62347/CAIV7004. eCollection 2025.
To investigate the correlation of serum uric acid (SUA) levels with ventricular diastolic dysfunction (DD) in the diabetic population.
Clinical data from 702 patients with type 2 diabetes mellitus (T2DM), including 394 males and 308 females, were retrospectively analyzed in this study. The data included demographic characteristics, biochemical test results, and echocardiography findings. Univariate and multivariate logistic regression analyses were performed to assess the association between SUA and DD. Additionally, the diagnostic efficacies of SUA and the multivariate logistic regression model (Logit P) for DD were evaluated using receiver operating characteristic (ROC) curves.
Compared to T2DM patients with normal diastolic function, those with DD had a higher prevalence of hypertension, older age, longer diabetes duration, elevated levels of low-density lipoprotein cholesterol (LDL-c), total cholesterol (TC), blood urea nitrogen (BUN), SUA, and hemoglobin A1c (HbA1c), as well as lower levels of 1,5-anhydroglucitol (1,5-AG) and estimated glomerular filtration rate (eGFR) (P<0.05). As indicated by the Logistic regression analysis, gender, age, and SUA were independent risk factors for DD (P<0.05). Women had a 47.8% lower risk of DD compared to men [95% CI (0.318-0.718)]. The risk of DD increased by 6.8% for each one-year rise in age [OR 1.068, 95% CI (1.051-1.085)] and by 0.5% for each 1 mmol/L increase in SUA [OR 1.005, 95% CI (1.003-1.007)]. The regression model incorporating sex, age, and SUA exhibited an area under the curve (AUC) of 0.753 (95% CI 0.712-0.794) for diagnosing DD, with a sensitivity of 65.65% and specificity of 78.65%.
Gender, age, and SUA were independent factors influencing the development of DD in T2DM patients. Among them, SUA is the only modifiable factor. Early and long-term control of SUA levels is essential to reduce the risk of DD in T2DM patients.
探讨糖尿病患者血清尿酸（SUA）水平与心室舒张功能障碍（DD）的相关性。
本研究回顾性分析了702例2型糖尿病（T2DM）患者的临床资料，其中男性394例，女性308例。数据包括人口统计学特征、生化检测结果和超声心动图检查结果。进行单因素和多因素逻辑回归分析，以评估SUA与DD之间的关联。此外，使用受试者工作特征（ROC）曲线评估SUA和多因素逻辑回归模型（Logit P）对DD的诊断效能。
与舒张功能正常的T2DM患者相比，DD患者高血压患病率更高、年龄更大、糖尿病病程更长、低密度脂蛋白胆固醇（LDL-c）、总胆固醇（TC）、血尿素氮（BUN）、SUA和糖化血红蛋白（HbA1c）水平升高，而1,5-脱水葡萄糖醇（1,5-AG）和估算肾小球滤过率（eGFR）水平更低（P<0.05）。逻辑回归分析表明，性别、年龄和SUA是DD的独立危险因素（P<0.05）。女性发生DD的风险比男性低47.8% [95%置信区间（0.318 - 0.718）]。年龄每增加1岁，DD风险增加6.8% [比值比（OR）1.068，95%置信区间（1.051 - 1.085）]，SUA每升高1 mmol/L，DD风险增加0.5% [OR 1.005，95%置信区间（1.003 - 1.007）]。纳入性别、年龄和SUA的回归模型诊断DD的曲线下面积（AUC）为0.753（95%置信区间0.712 - 0.794），敏感性为65.65%，特异性为78.65%。
性别、年龄和SUA是影响T2DM患者发生DD的独立因素。其中，SUA是唯一可改变的因素。早期和长期控制SUA水平对于降低T2DM患者发生DD的风险至关重要。
