Huang Qianhao, Huang Yifan, Xiong Dongfeng, Zhuang Xuan, Chen Yuedong
The Key Laboratory of Urinary Tract Tumours and Calculi, Department of Urology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
The School of Clinical Medicine, Fujian Medical University, Fuzhou, China.
Transl Androl Urol. 2025 Mar 30;14(3):855-862. doi: 10.21037/tau-2024-765. Epub 2025 Mar 26.
Penile cancer is a rare tumour with a global annual incidence of 0.2 to 1 case per 100,000 men. Sarcomatoid carcinoma (SC) of the penis, also known as carcinosarcoma, is a rare form of squamous cell carcinoma (SCC) of the penis, accounting for approximately 1-2% of all penile cancers. We report a case of SC of the penis in a 60-year-old man.
A 60-year-old male patient presented, with a penile glans nodule that had developed over a two-month period. The patient was employed in the agricultural sector and had a history of hypertension, which he asserted was effectively managed through pharmacological intervention. A specialist examination revealed an enlarged, cauliflower-shaped penile head with surface ulceration, approximately the size of 2 cm. He underwent a partial resection and bilateral inguinal and pelvic lymph node dissection. Histopathology demonstrated that the tumour cells were p63-positive, while p16 expression was absent. Vimentin and p53 were positive in the sarcomatous component, and the morphology and immunohistochemistry were consistent with penile SC. After six months, there was no evidence of disease progression.
The diagnosis of SC is challenging, and an accurate diagnosis is the first step towards successful treatment, which has a higher probability of success. It presents as a large, aggressive tumour, usually associated with lymph node metastasis and poor prognosis. Our case adds to the literature and reviews the treatment options for this rare disease and the poor prognosis associated with this malignancy.
阴茎癌是一种罕见肿瘤，全球每年发病率为每10万名男性中有0.2至1例。阴茎肉瘤样癌（SC），也称为癌肉瘤，是阴茎鳞状细胞癌（SCC）的一种罕见形式，约占所有阴茎癌的1-2%。我们报告一例60岁男性阴茎SC病例。
一名60岁男性患者就诊，其阴茎龟头出现一个两个月内形成的结节。该患者从事农业工作，有高血压病史，他称通过药物干预病情得到有效控制。专科检查发现阴茎头部增大，呈菜花状，表面有溃疡，大小约2厘米。他接受了部分切除术及双侧腹股沟和盆腔淋巴结清扫术。组织病理学显示肿瘤细胞p63阳性，而p16无表达。波形蛋白和p53在肉瘤成分中呈阳性，形态学和免疫组化结果与阴茎SC一致。六个月后，无疾病进展迹象。
SC的诊断具有挑战性，准确诊断是成功治疗的第一步，成功治疗的可能性更高。它表现为一种大的、侵袭性肿瘤，通常伴有淋巴结转移且预后较差。我们的病例丰富了文献，并回顾了这种罕见疾病的治疗选择以及与这种恶性肿瘤相关的不良预后。
