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未得到充分重视的膀胱活动低下

The underappreciated underactive bladder.

作者信息

Razi Basil, Zhuo Kevin, Cole-Clark Dane, Chung Amanda

机构信息

Department of Urology, Royal North Shore Hospital, St Leonards, NSW, Australia.

North Shore Urology Research Group (NSURG), St Leonards, NSW, Australia.

出版信息

Transl Androl Urol. 2025 Mar 30;14(3):841-847. doi: 10.21037/tau-2025-61. Epub 2025 Mar 26.

DOI:10.21037/tau-2025-61
PMID:40226053
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11986530/
Abstract

Slow urinary flow is a common lower urinary tract symptom (LUTS) that frequently prompts men to consult their primary care physician. While bladder outlet obstruction (BOO) is well recognised, underactive bladder (UAB) remains underappreciate despite its significant impact on quality of life. This review highlights the pathophysiology, clinical features, and diagnostic challenges and approach to UAB in men. Improving recognition of UAB as a distinct condition separate from other LUTS aetiologies, it can facilitate earlier diagnosis and management. Slow urinary flow is highly prevalent, particularly in an ageing population. UAB is characterised by impaired detrusor muscle activity, leading to slow urinary flow, hesitancy, straining and incomplete bladder emptying. The overlap in symptoms with BOO often leads to misdiagnosis, delaying appropriate intervention. UAB has multiple underlying causes including, neurogenic, myogenic, iatrogenic and idiopathic factors. Diagnosis is further complicated by the limited availability of urodynamic studies, the gold standard for assessing detrusor underactivity. Current management options remain limited with no definitive treatments. Current strategies focus on behavioural modifications, pelvic floor exercises, timed voiding, sacral neuromodulation and intermittent catheterisation. Increased awareness of UAB among primary care physicians and urologists is essential for timely diagnosis and intervention. Recognition of UAB as a distinct clinical entity will lead to a reduction in potential complications and significant improvement in the quality of life of affected men.

摘要

排尿缓慢是一种常见的下尿路症状(LUTS),常促使男性咨询其初级保健医生。虽然膀胱出口梗阻(BOO)已得到充分认识,但膀胱活动低下(UAB)尽管对生活质量有重大影响,却仍未得到充分重视。本文综述了男性UAB的病理生理学、临床特征、诊断挑战及诊断方法。提高对UAB作为一种与其他LUTS病因不同的独特病症的认识,有助于早期诊断和管理。排尿缓慢非常普遍,尤其是在老年人群中。UAB的特征是逼尿肌活动受损,导致排尿缓慢、排尿犹豫、用力排尿及膀胱排空不全。其症状与BOO的重叠常导致误诊,延误适当干预。UAB有多种潜在病因,包括神经源性、肌源性、医源性和特发性因素。尿动力学检查是评估逼尿肌活动低下的金标准,但因可用性有限,使诊断进一步复杂化。目前的治疗选择仍然有限,尚无明确的治疗方法。当前的策略侧重于行为改变、盆底肌锻炼、定时排尿、骶神经调节和间歇性导尿。提高初级保健医生和泌尿科医生对UAB的认识对于及时诊断和干预至关重要。将UAB识别为一种独特的临床实体将减少潜在并发症,并显著改善受影响男性的生活质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e216/11986530/d42118417271/tau-14-03-841-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e216/11986530/25fcb4fe5f72/tau-14-03-841-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e216/11986530/d42118417271/tau-14-03-841-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e216/11986530/25fcb4fe5f72/tau-14-03-841-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e216/11986530/d42118417271/tau-14-03-841-f2.jpg

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本文引用的文献

1
Summary Paper on Underactive Bladder from the European Association of Urology Guidelines on Non-neurogenic Male Lower Urinary Tract Symptoms.欧洲泌尿外科学会非神经原性男性下尿路症状指南关于膀胱过度活动症的概要文件
Eur Urol. 2024 Sep;86(3):213-220. doi: 10.1016/j.eururo.2024.04.004. Epub 2024 Apr 21.
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Sacral Neuromodulation: Device Improvement and Current Applications in Urology.骶神经调节:设备改进及在泌尿科的当前应用。
Medicina (Kaunas). 2024 Mar 20;60(3):509. doi: 10.3390/medicina60030509.
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Underactive Bladder and Detrusor Underactivity: New Advances and Prospectives.
膀胱过度活动症和逼尿肌活动低下:新进展与展望。
Int J Mol Sci. 2023 Oct 24;24(21):15517. doi: 10.3390/ijms242115517.
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Aging and urinary control: Alterations in the brain-bladder axis.衰老与尿控:脑-膀胱轴的改变。
Aging Cell. 2023 Dec;22(12):e13990. doi: 10.1111/acel.13990. Epub 2023 Sep 22.
5
Urodynamics in the evaluation of lower urinary tract symptoms in young adult men: A systematic review.尿动力学在评估年轻成年男性下尿路症状中的应用:一项系统综述。
Indian J Urol. 2023 Apr-Jun;39(2):97-106. doi: 10.4103/iju.iju_160_22. Epub 2023 Mar 31.
6
The bladder contractility and bladder outlet obstruction indices in adult women. Results of a global Delphi consensus study.成年女性的膀胱收缩力和膀胱出口梗阻指数。全球德尔菲共识研究的结果。
Neurourol Urodyn. 2023 Feb;42(2):453-462. doi: 10.1002/nau.25114. Epub 2022 Dec 16.
7
Efficacy of TAC-302 for patients with detrusor underactivity and overactive bladder: a randomized, double-blind, placebo-controlled phase 2 study.TAC-302 治疗逼尿肌活动低下和膀胱过度活动症患者的疗效:一项随机、双盲、安慰剂对照的 2 期研究。
World J Urol. 2022 Nov;40(11):2799-2805. doi: 10.1007/s00345-022-04163-4. Epub 2022 Oct 7.
8
Evolution of healthcare costs for lower urinary tract symptoms associated with benign prostatic hyperplasia.下尿路症状相关良性前列腺增生的医疗保健成本演变。
Int Urol Nephrol. 2022 Nov;54(11):2797-2803. doi: 10.1007/s11255-022-03296-0. Epub 2022 Jul 29.
9
Two-Staged Sacral Neuromodulation for the Treatment of Nonobstructive Urinary Retention: A Multicenter Study Assessing Predictors of Success.两阶段骶神经调节治疗非梗阻性尿潴留:一项评估成功预测因素的多中心研究
Neuromodulation. 2023 Dec;26(8):1823-1830. doi: 10.1016/j.neurom.2022.04.042. Epub 2022 Jun 9.
10
Muscarinic-3-receptor positive allosteric modulator ASP8302 in patients with underactive bladder. A randomized controlled trial.毒蕈碱型乙酰胆碱受体 3 正向变构调节剂 ASP8302 治疗膀胱活动低下症患者的随机对照试验。
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