透析患者和肾移植受者的癌症风险：一项加泰罗尼亚队列研究，2003 - 2021年
Cancer risks in people on dialysis and kidney transplant recipients: a Catalan cohort study, 2003-21.
作者信息
Oliveras Laia, Pareja Laura, Ribes Josepa, Comas Jordi, Couceiro Carlos, Favà Àlex, Codina Sergi, Coloma Ana, Manonelles Anna, Lloberas Nuria, Melilli Edoardo, Martinez-Carbonell Elisenda, Gálvez Jordi, Mosteiro Sonia, Tort Jaume, Borràs Josep M, Cruzado Josep M, Montero Nuria
机构信息
Hospital Universitari de Bellvitge, Nephrology Department, L'Hospitalet de Llobregat, Spain.
Biomedical Research Institute (IDIBELL), Hospital Duran i Reynals, Barcelona, Spain.
出版信息
Clin Kidney J. 2025 Mar 20;18(4):sfaf077. doi: 10.1093/ckj/sfaf077. eCollection 2025 Apr.
BACKGROUND
People with kidney failure have a higher risk of cancer compared with age- and sex-matched individuals in the general population, yet data from southern Europe are limited. This study explores cancer incidence in the kidney failure population in Catalonia.
METHODS
We identified cancer cases through linkage of the Catalan Kidney Registry with Catalan cancer databases. Standardized incidence ratios (SIRs) were calculated for all-site and site-specific cancers in people on dialysis and kidney transplant recipients.
RESULTS
We described the epidemiology of cancer in 21 595 people on dialysis and 8037 kidney transplant recipients in Catalonia (2003-21). Cancer risk was more than two times higher in people on dialysis (SIR 2.11, 95% CI 2.02-2.19) and nearly four times higher in kidney transplant recipients (SIR 3.82, 95% CI 3.65-3.99) compared with the general population. Risks varied by cancer site, with a significantly higher incidence of kidney and thyroid cancers in the dialysis cohort, and skin cancer in the transplant cohort. The highest cancer risks were observed in the youngest, those with glomerular diseases, and those with the longest time since transplantation.
CONCLUSIONS
People with kidney failure face a high burden of cancer, particularly after kidney transplantation. Understanding the epidemiology of cancer in the kidney failure population is crucial for shaping health policies.
背景
与普通人群中年龄和性别匹配的个体相比，肾衰竭患者患癌症的风险更高，但来自南欧的数据有限。本研究探讨加泰罗尼亚肾衰竭人群中的癌症发病率。
方法
我们通过将加泰罗尼亚肾脏登记处与加泰罗尼亚癌症数据库相链接来确定癌症病例。计算了透析患者和肾移植受者中所有部位和特定部位癌症的标准化发病率（SIR）。
结果
我们描述了加泰罗尼亚21595名透析患者和8037名肾移植受者的癌症流行病学情况（2003 - 2021年）。与普通人群相比，透析患者的癌症风险高出两倍多（SIR 2.11，95%CI 2.02 - 2.19），肾移植受者的癌症风险高出近四倍（SIR 3.82，95%CI 3.65 - 3.99）。癌症风险因癌症部位而异，透析队列中肾癌和甲状腺癌的发病率显著较高，移植队列中皮肤癌的发病率较高。在最年轻的人群、患有肾小球疾病的人群以及移植后时间最长的人群中观察到最高的癌症风险。
结论
肾衰竭患者面临着很高的癌症负担，尤其是在肾移植后。了解肾衰竭人群中的癌症流行病学对于制定卫生政策至关重要。
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