Lin Yibin, Lin Qiaoming, Guan Qi, Chen Danru, Zhou Yan, Li Sang
Department of Gynecology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital Fuzhou 350014, Fujian, PR China.
Am J Cancer Res. 2025 Mar 15;15(3):1335-1345. doi: 10.62347/BXZM8857. eCollection 2025.
The immune system's role in cancer development and progression is receiving increasing attention. Endometrial cancer, common gynecological malignancy, has exhibited promising responses to immunotherapies. This study aims to assess the prognostic significance of various immune cell subsets in endometrial cancer, focusing on potential novel biomarkers and therapeutic targets. A systematic literature review and meta-analysis were conducted. Eleven eligible studies, comprising 2,319 patients with endometrial cancer, were included. The primary outcome was the association between levels of immune cell types, particularly CD8+ T cells, and overall prognosis. The meta-analysis found that high levels of tumor-infiltrating lymphocytes (TILs), particularly CD8+ T cells, were significantly associated with better overall prognosis in endometrial cancer patients. These findings suggest that the tumor immune microenvironment plays a crucial role in endometrial cancer prognosis. This meta-analysis indicates that higher levels of CD8+ T cells in the tumor microenvironment are linked to improved prognosis in endometrial cancer, underscoring the immune system's potential in prognostication and therapy.
免疫系统在癌症发生和发展中的作用正受到越来越多的关注。子宫内膜癌作为常见的妇科恶性肿瘤，已显示出对免疫疗法有良好反应。本研究旨在评估各种免疫细胞亚群在子宫内膜癌中的预后意义，重点关注潜在的新型生物标志物和治疗靶点。我们进行了一项系统的文献综述和荟萃分析。纳入了11项符合条件的研究，共2319例子宫内膜癌患者。主要结局是免疫细胞类型水平，特别是CD8 + T细胞水平与总体预后之间的关联。荟萃分析发现，肿瘤浸润淋巴细胞（TILs）水平较高，尤其是CD8 + T细胞，与子宫内膜癌患者更好的总体预后显著相关。这些发现表明，肿瘤免疫微环境在子宫内膜癌预后中起着关键作用。该荟萃分析表明，肿瘤微环境中较高水平的CD8 + T细胞与子宫内膜癌预后改善相关，强调了免疫系统在预后评估和治疗中的潜力。
