糖原积累通过靶向Hippo信号通路驱动肝癌发生。 - Suppr

Glycogen accumulation drives hepatocarcinogenesis by targeting the Hippo signaling pathway.

作者信息

Liang Weicheng, Zhang Qi

机构信息

Biotherapy Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Cell-gene Therapy Translational Medicine Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

出版信息

Liver Res. 2022 Aug 1;6(3):198-200. doi: 10.1016/j.livres.2022.07.001. eCollection 2022 Sep.

DOI:10.1016/j.livres.2022.07.001

PMID:40226506

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11985510/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/75e8/11985510/fab33bfaf191/gr1.jpg

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Liquid-liquid phase separation drives cellular function and dysfunction in cancer.

Nat Rev Cancer. 2022 Apr;22(4):239-252. doi: 10.1038/s41568-022-00444-7. Epub 2022 Feb 11.

Hippo signalling in the liver: role in development, regeneration and disease.

Nat Rev Gastroenterol Hepatol. 2022 May;19(5):297-312. doi: 10.1038/s41575-021-00571-w. Epub 2022 Jan 21.

Glycogen accumulation and phase separation drives liver tumor initiation.

Cell. 2021 Oct 28;184(22):5559-5576.e19. doi: 10.1016/j.cell.2021.10.001. Epub 2021 Oct 21.

Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?

Nat Rev Cancer. 2016 Oct;16(10):635-49. doi: 10.1038/nrc.2016.77. Epub 2016 Sep 16.

Targeting glycogen metabolism in bladder cancer.

Nat Rev Urol. 2015 Jul;12(7):383-91. doi: 10.1038/nrurol.2015.111. Epub 2015 May 26.

Hippo signalling: liver size regulation and beyond.

Clin Res Hepatol Gastroenterol. 2011 May;35(5):344-6. doi: 10.1016/j.clinre.2011.01.012. Epub 2011 Mar 5.

Glycogen storage disease type I and G6Pase-β deficiency: etiology and therapy.

Nat Rev Endocrinol. 2010 Dec;6(12):676-88. doi: 10.1038/nrendo.2010.189. Epub 2010 Oct 26.

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver.

Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1437-42. doi: 10.1073/pnas.0911427107. Epub 2010 Jan 4.

Understanding the Warburg effect: the metabolic requirements of cell proliferation.

Science. 2009 May 22;324(5930):1029-33. doi: 10.1126/science.1160809.

Elucidation of a universal size-control mechanism in Drosophila and mammals.

Cell. 2007 Sep 21;130(6):1120-33. doi: 10.1016/j.cell.2007.07.019.

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Glycogen accumulation drives hepatocarcinogenesis by targeting the Hippo signaling pathway.

Liver Res. 2022 Aug 1;6(3):198-200. doi: 10.1016/j.livres.2022.07.001. eCollection 2022 Sep.

Glycogen accumulation and phase separation drives liver tumor initiation.

Cell. 2021 Oct 28;184(22):5559-5576.e19. doi: 10.1016/j.cell.2021.10.001. Epub 2021 Oct 21.

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Cancer Lett. 2011 Mar 28;302(2):91-9. doi: 10.1016/j.canlet.2010.12.008. Epub 2011 Jan 17.

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Cell Mol Biol (Noisy-le-grand). 2023 Dec 20;69(14):114-120. doi: 10.14715/cmb/2023.69.14.18.

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Mol Cell. 2021 Dec 2;81(23):4768-4770. doi: 10.1016/j.molcel.2021.11.008.

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Oncogene. 2025 May 3. doi: 10.1038/s41388-025-03430-z.

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Oncogene. 2020 Jan;39(5):1125-1139. doi: 10.1038/s41388-019-1050-9. Epub 2019 Oct 11.

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Cancer Lett. 2023 Jul 1;565:216210. doi: 10.1016/j.canlet.2023.216210. Epub 2023 May 5.

本文引用的文献

Liquid-liquid phase separation drives cellular function and dysfunction in cancer.

Nat Rev Cancer. 2022 Apr;22(4):239-252. doi: 10.1038/s41568-022-00444-7. Epub 2022 Feb 11.

Hippo signalling in the liver: role in development, regeneration and disease.

Nat Rev Gastroenterol Hepatol. 2022 May;19(5):297-312. doi: 10.1038/s41575-021-00571-w. Epub 2022 Jan 21.

Glycogen accumulation and phase separation drives liver tumor initiation.

Cell. 2021 Oct 28;184(22):5559-5576.e19. doi: 10.1016/j.cell.2021.10.001. Epub 2021 Oct 21.

Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?

Nat Rev Cancer. 2016 Oct;16(10):635-49. doi: 10.1038/nrc.2016.77. Epub 2016 Sep 16.

Targeting glycogen metabolism in bladder cancer.

Nat Rev Urol. 2015 Jul;12(7):383-91. doi: 10.1038/nrurol.2015.111. Epub 2015 May 26.

Hippo signalling: liver size regulation and beyond.

Clin Res Hepatol Gastroenterol. 2011 May;35(5):344-6. doi: 10.1016/j.clinre.2011.01.012. Epub 2011 Mar 5.

Glycogen storage disease type I and G6Pase-β deficiency: etiology and therapy.

Nat Rev Endocrinol. 2010 Dec;6(12):676-88. doi: 10.1038/nrendo.2010.189. Epub 2010 Oct 26.

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Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1437-42. doi: 10.1073/pnas.0911427107. Epub 2010 Jan 4.

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Science. 2009 May 22;324(5930):1029-33. doi: 10.1126/science.1160809.

Elucidation of a universal size-control mechanism in Drosophila and mammals.

Cell. 2007 Sep 21;130(6):1120-33. doi: 10.1016/j.cell.2007.07.019.

Glycogen accumulation drives hepatocarcinogenesis by targeting the Hippo signaling pathway.

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