重编程癌症中的葡萄糖代谢：能否将其用于癌症治疗？
Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?
作者信息
Hay Nissim
机构信息
Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607 and Research and Development Section, Jesse Brown VA Medical Center, Chicago, Illinois 60612, USA.
出版信息
Nat Rev Cancer. 2016 Oct;16(10):635-49. doi: 10.1038/nrc.2016.77. Epub 2016 Sep 16.
Abstract
In recent years there has been a growing interest among cancer biologists in cancer metabolism. This Review summarizes past and recent advances in our understanding of the reprogramming of glucose metabolism in cancer cells, which is mediated by oncogenic drivers and by the undifferentiated character of cancer cells. The reprogrammed glucose metabolism in cancer cells is required to fulfil anabolic demands. This Review discusses the possibility of exploiting the reprogrammed glucose metabolism for therapeutic approaches that selectively target cancer cells.
摘要
近年来，癌症生物学家对癌症代谢的兴趣日益浓厚。本综述总结了我们在理解癌细胞中葡萄糖代谢重编程方面的过去和近期进展，这种重编程由致癌驱动因素和癌细胞的未分化特征介导。癌细胞中重编程的葡萄糖代谢是满足合成代谢需求所必需的。本综述讨论了利用重编程的葡萄糖代谢开发选择性靶向癌细胞的治疗方法的可能性。
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本文引用的文献
1
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Nat Chem Biol. 2016 Jun;12(6):452-8. doi: 10.1038/nchembio.2070. Epub 2016 Apr 25.
2
PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations.用于癌症治疗的PD-L1（B7-H1）和PD-1通路阻断：作用机制、反应生物标志物及联合应用
Sci Transl Med. 2016 Mar 2;8(328):328rv4. doi: 10.1126/scitranslmed.aad7118.
3
Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.鉴定一种3-磷酸甘油酸脱氢酶小分子抑制剂以靶向癌症中的丝氨酸生物合成。
Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1778-83. doi: 10.1073/pnas.1521548113. Epub 2016 Feb 1.
4
Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton.磷酸肌醇3激酶通过从肌动蛋白细胞骨架动员醛缩酶来调节糖酵解。
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5
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