利用系统发育分析检测丙型肝炎病毒1b型传播簇的国内和国际层面——中国，1989 - 2021年

Using Phylogenetic Analysis to Detect National and International Dimensions of Hepatitis C Virus 1b Transmission Clusters - China, 1989-2021.

作者信息

Jiang He, Liang Shujia, Wu Xiuling, Huang Jinghua, Li Bo, Liu Xuanhua, Meng Qin, Tang Shuai, Zhu Qiuying, Lan Guanghua

机构信息

Guangxi Key Laboratory of AIDS Prevention and Control and Achievement Transformation, Guangxi Center for Disease Prevention and Control, Nanning City, Guangxi Zhuang Autonomous Region, China.

Guangxi Key Laboratory for the Prevention and Control of Viral Hepatitis, Guangxi Center for Disease Prevention and Control, Nanning City, Guangxi Zhuang Autonomous Region, China.

出版信息

China CDC Wkly. 2025 Mar 28;7(13):435-440. doi: 10.46234/ccdcw2025.073.

DOI:10.46234/ccdcw2025.073

PMID:40226525

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11986446/

Abstract

WHAT IS ALREADY KNOWN ABOUT THIS TOPIC?: Phylogenetic analysis has revolutionized the detection and understanding of Hepatitis C Virus (HCV) transmission patterns.

WHAT IS ADDED BY THIS REPORT?: Three distinct transmission cluster patterns were identified across China: a large cluster with nationwide distribution, two medium clusters predominantly in the Central and Eastern China, and 103 small clusters scattered across 19 provincial-level administrative divisions (PLADs). Each cluster type exhibited unique characteristics of expansion risk and inter-provincial transmission patterns. No genetic linkages were found between Chinese sequences and those from other countries.

WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE?: These findings underscore the critical need for a comprehensive national molecular epidemiological surveillance network.

摘要

关于该主题已知的信息有哪些？：系统发育分析彻底改变了丙型肝炎病毒（HCV）传播模式的检测和理解。

本报告新增了哪些内容？：在中国各地识别出三种不同的传播聚集模式：一个分布于全国的大聚集群、两个主要位于中国中部和东部的中等聚集群，以及散布在19个省级行政区的103个小聚集群。每种聚集群类型都表现出独特的扩张风险特征和省际传播模式。在中国的序列与其他国家的序列之间未发现基因联系。

对公共卫生实践有何启示？：这些发现强调了建立全面的国家分子流行病学监测网络的迫切需求。