Bektasoglu Pinar Kuru, Somay Adnan, Hazneci Julide, Borekci Ali, Gurer Bora
Department of Neurosurgery, University of Health Sciences Türkiye, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Türkiye.
Department of Pathology, University of Health Sciences Türkiye, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Türkiye.
Sisli Etfal Hastan Tip Bul. 2025 Mar 18;59(1):59-63. doi: 10.14744/SEMB.2024.75301. eCollection 2025.
Epidural fibrosis occurs after laminectomy as part of the local repair mechanisms. Adhesion around the nervous tissue could cause pain and disability. In the current study, we investigated the possible antifibrotic effects of the plasminogen activator inhibitor-1 (PAI-1) antagonists in a rat laminectomy model.
The rats were randomly assigned to the control, the TM5441, and the TM5484 groups (n=6 per group). In the control group, just a laminectomy was performed. In the treatment groups, intragastric administration of PAI-1 antagonists was done after skin closure. Epidural fibrosis was investigated macroscopically and histopathologically four weeks later.
In the TM5441 and TM5484 groups, the macroscopic epidural fibrosis score was less than the control group (p<0.001 for both groups). Microscopic epidural fibrosis score was also decreased in the TM5441 and TM5484 groups (p>0.05 for both groups). Fibroblast cell density classification scores in the TM5441 and TM5484 groups were lower when compared to the control group (p>0.05 for both groups). Fibrosis thickness was lower in the TM5441 and TM5484 groups when compared to the control group (p<0.01 for both groups).
Plasminogen activator inhibitor-1 antagonists could be a treatment alternative for the prevention of epidural fibrosis.
椎板切除术后硬膜外纤维化作为局部修复机制的一部分而发生。神经组织周围的粘连可导致疼痛和功能障碍。在本研究中，我们在大鼠椎板切除模型中研究了纤溶酶原激活物抑制剂-1（PAI-1）拮抗剂可能的抗纤维化作用。
将大鼠随机分为对照组、TM5441组和TM5484组（每组n = 6）。对照组仅行椎板切除术。在治疗组中，皮肤缝合后进行PAI-1拮抗剂的胃内给药。四周后对硬膜外纤维化进行宏观和组织病理学研究。
在TM5441组和TM5484组中，宏观硬膜外纤维化评分低于对照组（两组均p < 0.001）。TM5441组和TM5484组的微观硬膜外纤维化评分也降低（两组均p > 0.05）。与对照组相比，TM5441组和TM5484组的成纤维细胞密度分类评分较低（两组均p > 0.05）。与对照组相比，TM5441组和TM5484组的纤维化厚度较低（两组均p < 0.01）。
纤溶酶原激活物抑制剂-1拮抗剂可能是预防硬膜外纤维化的一种治疗选择。
