Xu Xinqi, Yang Tingyu, An Jiapan, Li Bin, Dou Zhimin
The First Hospital of Lanzhou University & The First School of Clinical Medicine, Lanzhou University, Lanzhou, China.
Department of Critical Care Medicine, The First Hospital of Lanzhou University, Lanzhou, China.
Front Immunol. 2025 Mar 28;16:1575554. doi: 10.3389/fimmu.2025.1575554. eCollection 2025.
Sepsis is defined as a condition related to infection that manifests with multiorgan dysfunction, representing a life-threatening state. Consequently, severe complications frequently occur, with liver injury being one of the most prevalent serious complications of sepsis. Liver dysfunction during sepsis serves as an independent predictor of mortality. This review provides a comprehensive overview of current research on sepsis-induced liver injury (SILI), encompassing the clinical manifestations, diagnostic criteria, pathogenesis and therapeutic strategies associated with this condition. SILI may manifest as hypoxic hepatitis due to ischemia and shock, cholestasis resulting from abnormal bile metabolism, or bile duct sclerosis. The pathophysiology of sepsis involves intricate interactions among the inflammatory response, oxidative stress, and cell death. All of these factors complicate treatment and represent potential targets for therapeutic intervention. Furthermore, this review addresses the limitations inherent in conventional therapies currently employed for managing SILI and emphasizes the potential of novel targeted strategies aimed at addressing the fundamental mechanisms underlying this condition.
脓毒症被定义为一种与感染相关的疾病，表现为多器官功能障碍，是一种危及生命的状态。因此，严重并发症经常发生，肝损伤是脓毒症最常见的严重并发症之一。脓毒症期间的肝功能障碍是死亡率的独立预测指标。本综述全面概述了目前关于脓毒症诱导的肝损伤（SILI）的研究，包括与该疾病相关的临床表现、诊断标准、发病机制和治疗策略。SILI可能表现为因缺血和休克导致的缺氧性肝炎、胆汁代谢异常引起的胆汁淤积或胆管硬化。脓毒症的病理生理学涉及炎症反应、氧化应激和细胞死亡之间的复杂相互作用。所有这些因素都使治疗复杂化，并代表了治疗干预的潜在靶点。此外，本综述阐述了目前用于治疗SILI的传统疗法所固有的局限性，并强调了旨在解决该疾病根本机制的新型靶向策略的潜力。
