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Treatment Modalities for Aromatase Inhibitor-Associated Musculoskeletal Syndrome (AIMSS): A Scoping Review of Prospective Treatment Studies.

作者信息

Bobo Justin Andrew, Lubrano Barbara, Rosario-Concepcion Raul, Cuartas-Abril Alejandra, Advani Pooja, Chumsri Saranya, Bruce Barbara K

机构信息

Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.

Department of Psychiatry & Psychology, Mayo Clinic, Jacksonville, FL, USA.

出版信息

J Pain Res. 2025 Apr 7;18:1853-1889. doi: 10.2147/JPR.S492891. eCollection 2025.


DOI:10.2147/JPR.S492891
PMID:40226826
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11989607/
Abstract

Aromatase inhibitors (AI's) are effective adjuvant treatments for postmenopausal patients with hormone receptor-positive breast cancer. However, AIs are often associated with diffuse joint and muscle pain, referred to as aromatase inhibitor-associated musculoskeletal syndrome (AIMSS), the symptoms of which are associated with negative impacts and reduced adherence to AI therapy. As more interventions for AIMSS continue to be investigated, a scoping review is needed to survey and summarize the types of interventions and outcomes assessed in studies conducted to date, which may help identify areas needing attention or additional focus in future research. Online databases were searched (from inception to January 8, 2025) to identify 74 reports from prospective studies of interventions for AIMSS pain, stiffness, or interference with functioning. Such interventions were classified as pharmacological (14 reports), complementary/alternative (43 reports), or rehabilitative (17 reports). Included papers required the presence of AIMSS symptoms at enrollment. Several interventions were deemed promising for reducing AIMSS symptoms based on positive results from individual reports, including duloxetine (3 reports from 2 studies), vitamin B12 (2 reports), vitamin D (2 reports), calcitonin (1 report), prednisolone (1 report), glucosamine and chondroitin (1 report), various mind-body (14 reports from 12 studies) and traditional medicine interventions (3 reports), and switching to another AI (1 report). Many positive findings were from uncontrolled studies or were from single studies that await replication in independent cohorts, and no studies focused on structured psychological interventions. The durations for all reviewed studies were brief relative to the expected 5-10-year course of AI therapy. Intervention effects on a wide range of outcomes were studied, including pain or stiffness (70 reports), functioning/disability (34 reports), quality of life (37 reports), mental health symptoms (25 reports), pain self-efficacy (4 reports), and AI persistence (3 reports). However, intervention effects on other important endpoints such as cancer recurrence, survival, healthcare utilization/costs, and caregiver experiences are unclear. The knowledge gaps and limitations identified in this scoping review constitute areas in urgent need of further research and attention.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a90c/11989607/83bd163506c8/JPR-18-1853-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a90c/11989607/cb7a2ca3bf2c/JPR-18-1853-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a90c/11989607/c5574a75888e/JPR-18-1853-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a90c/11989607/83bd163506c8/JPR-18-1853-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a90c/11989607/cb7a2ca3bf2c/JPR-18-1853-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a90c/11989607/c5574a75888e/JPR-18-1853-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a90c/11989607/83bd163506c8/JPR-18-1853-g0003.jpg

相似文献

[1]
Treatment Modalities for Aromatase Inhibitor-Associated Musculoskeletal Syndrome (AIMSS): A Scoping Review of Prospective Treatment Studies.

J Pain Res. 2025-4-7

[2]
Systemic therapies for preventing or treating aromatase inhibitor-induced musculoskeletal symptoms in early breast cancer.

Cochrane Database Syst Rev. 2022-1-10

[3]
Exercise therapies for preventing or treating aromatase inhibitor-induced musculoskeletal symptoms in early breast cancer.

Cochrane Database Syst Rev. 2020-1-29

[4]
Further Evidence That OPG rs2073618 Is Associated With Increased Risk of Musculoskeletal Symptoms in Patients Receiving Aromatase Inhibitors for Early Breast Cancer.

Front Genet. 2021-6-15

[5]
Management of aromatase inhibitor induced musculoskeletal symptoms in postmenopausal early Breast cancer: A systematic review and meta-analysis.

Crit Rev Oncol Hematol. 2017-1-22

[6]
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Support Care Cancer. 2022-10

[7]
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[8]
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Clin Cancer Res. 2024-7-1

[9]
Randomized, blinded trial of vitamin D3 for treating aromatase inhibitor-associated musculoskeletal symptoms (AIMSS).

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[10]
Association of Aromatase Inhibitor-Induced Musculoskeletal Symptoms with Central Sensitization-Related Symptoms: A Cross-Sectional Study.

Breast Care (Basel). 2024-8

本文引用的文献

[1]
Progressive relaxation training in patients with breast cancer receiving aromatase inhibitor therapy-randomized controlled trial.

PLoS One. 2024

[2]
The effectiveness of a combined exercise and psychological treatment programme on measures of nervous system sensitisation in adults with chronic musculoskeletal pain - a systematic review and meta-analysis.

BMC Musculoskelet Disord. 2024-2-14

[3]
Central Sensitization in Cancer Survivors and Its Clinical Implications: State of the Art.

J Clin Med. 2023-7-11

[4]
Antidepressants for pain management in adults with chronic pain: a network meta-analysis.

Cochrane Database Syst Rev. 2023-5-10

[5]
Diagnosing nociplastic pain in cancer survivors: a major step forward.

Br J Anaesth. 2023-5

[6]
Towards precision pain medicine for pain after cancer: the Cancer Pain Phenotyping Network multidisciplinary international guidelines for pain phenotyping using nociplastic pain criteria.

Br J Anaesth. 2023-5

[7]
Mat Pilates and belly dance: Effects on patient-reported outcomes among breast cancer survivors receiving hormone therapy and adherence to exercise.

Complement Ther Clin Pract. 2023-2

[8]
Comparison of Acupuncture vs Sham Acupuncture or Waiting List Control in the Treatment of Aromatase Inhibitor-Related Joint Pain: A Randomized Clinical Trial.

JAMA Netw Open. 2022-11-1

[9]
A Telehealth-Delivered Tai Chi Intervention (TaiChi4Joint) for Managing Aromatase Inhibitor-Induced Arthralgia in Patients With Breast Cancer During COVID-19: Longitudinal Pilot Study.

JMIR Form Res. 2022-6-21

[10]
Use of an alfa-lipoic, Methylsulfonylmethane, Boswellia serrata and Bromelain dietary supplement (OPERA®) for aromatase inhibitors-related arthralgia management (AIA): a prospective phase II trial (NCT04161833).

Med Oncol. 2022-6-6

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