Tang Huiru, Kan Chengxia, Zhang Kexin, Sheng Sufang, Qiu Hongyan, Ma Yujie, Wang Yuqun, Hou Ningning, Zhang Jingwen, Sun Xiaodong
Department of Endocrinology and Metabolism, Clinical Research Center, Shandong Provincial Key Medical and Health Discipline of Endocrinology, Affiliated Hospital of Shandong Second Medical University, Weifang, China.
J Cardiovasc Transl Res. 2025 Apr 14. doi: 10.1007/s12265-025-10620-3.
Cardiovascular disease remains a leading cause of mortality worldwide, driven by factors such as dysregulated lipid metabolism, oxidative stress, and inflammation. Recent studies highlight the critical roles of both glycerophospholipid and sphingosine- 1-phosphate metabolism in the pathogenesis of cardiovascular disorders. However, the contributions of glycerophospholipid-derived metabolites remain underappreciated. Glycerophospholipid metabolism generates bioactive molecules that contribute to endothelial dysfunction, lipid accumulation, and cardiac cell injury while also modulating inflammatory and oxidative stress responses. Meanwhile, sphingosine- 1-phosphate is a bioactive lipid mediator that regulates vascular integrity, inflammation, and cardiac remodeling through its G-protein-coupled receptors. The convergence of these pathways presents novel therapeutic opportunities, where dietary interventions such as omega- 3 polyunsaturated fatty acids and pharmacological targeting of sphingosine- 1-phosphate receptors could synergistically mitigate cardiovascular risk. This review underscores the need for further investigation into the interplay between glycerophospholipid metabolism and sphingosine- 1-phosphate signaling to advance targeted therapies for the prevention and management of cardiovascular disease.
心血管疾病仍然是全球主要的死亡原因，由脂质代谢失调、氧化应激和炎症等因素驱动。最近的研究强调了甘油磷脂和1-磷酸鞘氨醇代谢在心血管疾病发病机制中的关键作用。然而，甘油磷脂衍生代谢物的作用仍未得到充分认识。甘油磷脂代谢产生的生物活性分子会导致内皮功能障碍、脂质积累和心脏细胞损伤，同时还会调节炎症和氧化应激反应。与此同时，1-磷酸鞘氨醇是一种生物活性脂质介质，通过其G蛋白偶联受体调节血管完整性、炎症和心脏重塑。这些途径的交汇带来了新的治疗机会，例如ω-3多不饱和脂肪酸等饮食干预措施以及对1-磷酸鞘氨醇受体的药物靶向治疗可以协同降低心血管风险。这篇综述强调了进一步研究甘油磷脂代谢与1-磷酸鞘氨醇信号之间相互作用的必要性，以推进心血管疾病预防和管理的靶向治疗。
