Abdullah Abiha, Liu Zeyu, Molinari Michele
Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
Department of Surgery, University of California, Los Angeles, CA 90095, USA.
Cancers (Basel). 2025 Mar 22;17(7):1067. doi: 10.3390/cancers17071067.
Social determinants of health (SDOH) profoundly influence cancer outcomes. Disparities in these areas contribute to delayed diagnoses, limited access to advanced treatments, and poorer survival rates, disproportionately affecting marginalized populations. While advancements in cancer care have improved survival, these benefits remain unevenly distributed. This review examines the impact of SDOH on cancer care across multiple domains. It highlights the ways in which structural barriers exacerbate disparities in prevention, diagnosis, and treatment. Evidence-based interventions, including Medicaid expansion, culturally tailored patient navigation programs, increased diversity in clinical trials, telemedicine expansion, and the integration of SDOH screening into oncology workflows-offer promising strategies for addressing these inequities. By integrating these strategies into clinical practice and health policy, the healthcare system can foster a more just and inclusive future for cancer treatment and survivorship.
健康的社会决定因素（SDOH）对癌症治疗结果有着深远影响。这些领域的差异导致诊断延迟、获得先进治疗的机会有限以及生存率较低，对边缘化人群的影响尤为严重。虽然癌症护理的进步提高了生存率，但这些益处的分布仍然不均衡。本综述探讨了SDOH在多个领域对癌症护理的影响。它强调了结构性障碍如何加剧预防、诊断和治疗方面的差异。基于证据的干预措施，包括医疗补助扩大、针对不同文化背景的患者导航项目、增加临床试验的多样性、远程医疗扩展以及将SDOH筛查纳入肿瘤学工作流程，为解决这些不平等问题提供了有前景的策略。通过将这些策略纳入临床实践和卫生政策，医疗保健系统可以为癌症治疗和生存创造一个更加公正和包容的未来。
