Patruno Cataldo, Pelucchi Claudio, Galeone Carlotta, Emmi Martino, Amerio Paolo
Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Dermatol Pract Concept. 2025 Apr 1;15(2):4716. doi: 10.5826/dpc.1502a4716.
Prurigo nodularis is a chronic inflammatory skin disease with recent definition and relatively low prevalence. Information on prurigo nodularis, including its epidemiology, severity, and burden of disease, is still scanty.
We sought to review and summarize recent quantitative data on prurigo nodularis in Europe and to estimate the burden of disease in Italy, with a focus on moderate-to-severe prurigo nodularis.
We conducted a systematic literature review of recent studies on the epidemiology of prurigo nodularis in Europe, using PubMed/MEDLINE and EMBASE. The study selection process was conducted independently by two reviewers. Articles focusing on the severity of prurigo nodularis were also searched (non-systematically), and relevant information was extracted. Synthetic results were combined to population data to derive the best estimate of the burden of prurigo nodularis in Italian adults.
Five articles reporting data on incidence and/or prevalence of prurigo nodularis in European populations were identified. The prevalence of prurigo nodularis ranged from 6.5 to 111.0 cases per 100,000, with a median estimate of 32.7 cases per 100,000, the incidence ranging between 2.88 and 20 per 100,000 person-years. Five other studies reported data on the severity of prurigo nodularis, measured through pruritus scores, quality-of-life indexes and/or percentage of non-response to treatment. We estimated a total of 16,280 prevalent prurigo nodularis cases in Italy, of whom 6,073 had moderate-to-severe to very severe disease. Among the latter, 1,798 estimated cases were not controlled by standard treatments.
We retrieved and summarized recent epidemiological data on prurigo nodularis, evidencing a high burden of disease in Italy and other European countries.
结节性痒疹是一种慢性炎症性皮肤病，其定义较新且患病率相对较低。关于结节性痒疹的信息，包括其流行病学、严重程度和疾病负担，仍然匮乏。
我们试图回顾和总结欧洲近期关于结节性痒疹的定量数据，并估计意大利的疾病负担，重点关注中重度结节性痒疹。
我们使用PubMed/MEDLINE和EMBASE对欧洲近期关于结节性痒疹流行病学的研究进行了系统的文献综述。研究选择过程由两名评审员独立进行。还（非系统地）检索了关注结节性痒疹严重程度的文章，并提取了相关信息。将综合结果与人口数据相结合，以得出意大利成年人结节性痒疹疾病负担的最佳估计值。
确定了五篇报告欧洲人群中结节性痒疹发病率和/或患病率数据的文章。结节性痒疹的患病率为每10万人6.5至111.0例，中位数估计为每10万人32.7例，发病率为每10万人年2.88至20例。其他五项研究报告了通过瘙痒评分、生活质量指数和/或治疗无反应百分比衡量的结节性痒疹严重程度的数据。我们估计意大利共有16280例结节性痒疹患者，其中6073例患有中重度至非常严重的疾病。在后者中，估计有1798例病例未通过标准治疗得到控制。
我们检索并总结了近期关于结节性痒疹的流行病学数据，证明意大利和其他欧洲国家的疾病负担很高。
