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骨质疏松相关领域孟德尔随机化的研究热点与前沿分析：基于文献计量学和可视化分析的综述

Research hotspots and frontier analysis on Mendelian randomization in osteoporosis-related fields: A review based on bibliometric and visual analysis.

作者信息

Zeng Qingqing, Gui Sijie, Li Zhuolan, Wu Fei, Peng Dan, Zeng Guqing

机构信息

School of Nursing, University of South China, Hengyang, China.

Jiangbei Campus of The First Affiliated Hospital of Army Medical University (The 958th Hospital of Chinese People's Liberation Army), Chongqing, China.

出版信息

Medicine (Baltimore). 2025 Apr 11;104(15):e41961. doi: 10.1097/MD.0000000000041961.

DOI:10.1097/MD.0000000000041961
PMID:40228251
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11999391/
Abstract

This research seeks to thoroughly examine the present state and research hotspots in Mendelian randomization (MR) in osteoporosis (OP)-related fields, providing a reference for future research directions in this area. Following an exhaustive search of the Web of Science Core Collection database, our analysis utilized citation statistics for osteoporosis studies conducted from January 1, 2007, through March 15, 2024. Bibliometric and visual analyses were conducted using two online analysis systems, CiteSpace and VOSviewer. The analysis included a variety of dimensions, including the distribution of citations, authorship, published journals, year of publication, countries, co-occurrence keywords and keyword clustering. From 2007 to 2024, the number of publications in MR in OP-related fields showed an overall increased. High-impact publications and leading contributors were primarily from China, followed by the USA and England. The journal with the largest number of publications in MR in OP-related fields is the Journal of Bone and Mineral Research. Risk factor research, genome-wide associations, meta-analysis, fractures, and gene loci were the main research hotspots. Interdisciplinary integration, MR research combined with data from clinical trials and observational studies, represents the future development trend. Research on MR in OP-related fields has mainly been conducted in China, the USA, and England. The research hotspots were aimed at exploring the causative between risk factors and OP. Future studies are likely to center on multidisciplinary integration.

摘要

本研究旨在全面审视骨质疏松症（OP）相关领域孟德尔随机化（MR）的现状和研究热点，为该领域未来的研究方向提供参考。在对科学网核心合集数据库进行详尽检索后，我们的分析利用了2007年1月1日至2024年3月15日期间进行的骨质疏松症研究的引文统计数据。使用CiteSpace和VOSviewer这两个在线分析系统进行了文献计量和可视化分析。分析涵盖了多个维度，包括引文分布、作者、发表期刊、出版年份、国家、共现关键词和关键词聚类。2007年至2024年，OP相关领域MR的出版物数量总体呈上升趋势。高影响力出版物和主要贡献者主要来自中国，其次是美国和英国。OP相关领域MR出版物数量最多的期刊是《骨与矿物质研究杂志》。危险因素研究、全基因组关联研究、荟萃分析、骨折和基因位点是主要研究热点。跨学科整合，即MR研究与临床试验和观察性研究数据相结合，代表了未来的发展趋势。OP相关领域的MR研究主要在中国、美国和英国开展。研究热点旨在探索危险因素与OP之间的因果关系。未来的研究可能集中在多学科整合上。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c919/11999391/c0ebcbf38f04/medi-104-e41961-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c919/11999391/332ff8ce03af/medi-104-e41961-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c919/11999391/d0d5338eb774/medi-104-e41961-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c919/11999391/15380a43b925/medi-104-e41961-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c919/11999391/4072d45dc668/medi-104-e41961-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c919/11999391/22a3d9cdb5b5/medi-104-e41961-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c919/11999391/22355e8640bf/medi-104-e41961-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c919/11999391/c0ebcbf38f04/medi-104-e41961-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c919/11999391/332ff8ce03af/medi-104-e41961-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c919/11999391/d0d5338eb774/medi-104-e41961-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c919/11999391/15380a43b925/medi-104-e41961-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c919/11999391/4072d45dc668/medi-104-e41961-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c919/11999391/22a3d9cdb5b5/medi-104-e41961-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c919/11999391/22355e8640bf/medi-104-e41961-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c919/11999391/c0ebcbf38f04/medi-104-e41961-g007.jpg

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Research hotspots and frontier analysis on Mendelian randomization in osteoporosis-related fields: A review based on bibliometric and visual analysis.

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本文引用的文献

[1]
Causal Association of Telomere Length and Loss of Bone: a Directional Mendelian Randomization Study of Multi-Outcomes.

Appl Biochem Biotechnol. 2024-10

[2]
Hotspot Analysis and Frontier Exploration of Stem Cell Research in Intervertebral Disc Regeneration and Repair: A Bibliometric and Visualization Study.

World Neurosurg. 2024-4

[3]
Causal Relationships between Air Pollutant Exposure and Bone Mineral Density and the Risk of Bone Fractures: Evidence from a Two-Stage Mendelian Randomization Analysis.

Toxics. 2023-12-30

[4]
Tumor necrosis factor mediates the impact of PM on bone mineral density: Inflammatory proteome Mendelian randomization and colocalization analyses.

Ecotoxicol Environ Saf. 2024-1-15

[5]
The association of lipid metabolism with bone metabolism and the role of human traits: a Mendelian randomization study.

Front Endocrinol (Lausanne). 2023

[6]
Exploring Causal Relationships between Leukocyte Telomere Length, Sex Hormone-Binding Globulin Levels, and Osteoporosis Using Univariable and Multivariable Mendelian Randomization.

Orthop Surg. 2024-2

[7]
The Association Between SHBG and Osteoporosis: A NHANES Cross-Sectional Study and A Bidirectional Mendelian Randomization.

Calcif Tissue Int. 2024-3

[8]
Bibliometric and Visualization Analysis of Biomechanical Research on Lumbar Intervertebral Disc.

J Pain Res. 2023-10-17

[9]
The associations of alcoholic liver disease and nonalcoholic fatty liver disease with bone mineral density and the mediation of serum 25-Hydroxyvitamin D: A bidirectional and two-step Mendelian randomization.

PLoS One. 2023

[10]
Association of Bone Mineral Density and Bone Turnover Markers with the Risk of Diabetes: Hong Kong Osteoporosis Study and Mendelian Randomization.

J Bone Miner Res. 2023-12

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