多价蛇抗毒素对三种蝰蛇（贝氏蝰蛇；林奈，1758年，角蝰；林奈，1758年和草原蝰；博特格，1890年）毒液的副特异性作用研究。

Investigation of paraspecific effects of polyvalent snake antivenom on the venom of three vipers (Vipera berus berus; Linnaeus 1758, Vipera ammodytes ammodytes; Linnaeus, 1758 and Montivipera raddei; Boettger, 1890).

作者信息

Numanoglu Cevik Yasemin, Altun Derya, Serin Metin, Namli Bozkurt Edibe Nurzen, Bozyigit Ilhan, Icigen Halit Ozkan, Kanat Mehmet Ali

机构信息

Microbiology and Reference Laboratory and Biological Products Department, Republic of Turkish Ministry of Health General Directorate of Public Health, 06430, Ankara, Turkiye.

Tuberculosis Department, Republic of Turkish Ministry of Health General Directorate of Public Health 06430, Ankara, Turkiye.

出版信息

Toxicon. 2025 Jun;260:108349. doi: 10.1016/j.toxicon.2025.108349. Epub 2025 Apr 12.

DOI:10.1016/j.toxicon.2025.108349

PMID:40228632

Abstract

OBJECTIVE

The aim was to investigate the paraspecific efficiacy of the National HSGM-polyvalent snake antivenom, which is used in the treatment of snakebite poisoning cases in Turkey, on Vipera ammodytes ammodytes and Vipera berus berus snakes that live widely in Europe and Montivipera raddei venoms that live in Turkey and Armenia.

METHOD

The paraspecific efficiacy of the antivenom on these three venoms were determined using the test method for neutralization of the lethal effect of the venom in mice specified in the European pharmacopoeia.

CONCLUSION

It was observed that HSGM-PVSAV produced using Vipera ammodytes montandoni, Macrovipera lebetina obtusa and Montivipera xanthina venoms showed an effect above the European pharmacopoeia limits against all three snake venoms.

摘要