O'Keefe J C, Butrous G S, Dymond D S, Littlejohns P, Peters N, Banim S O
Postgrad Med J. 1985 May;61(715):419-21. doi: 10.1136/pgmj.61.715.419.
Serious ventricular arrhythmias are known to occur in patients with long QT intervals. We describe a case of torsade de pointes occurring in a patient with a prolonged QT interval while taking a 1000 calorie diet, diethylpropion hydrochloride (Tenuate Dospan) and bendrofluazide. In patients with long QT intervals, hypokalaemia and drugs which further delay repolarization may facilitate the development of life threatening arrhythmias.
已知长QT间期患者会发生严重室性心律失常。我们描述了1例长QT间期患者在采用1000卡路里饮食、服用盐酸二乙丙胺苯丙酮(安非拉酮)和苄氟噻嗪时发生尖端扭转型室速的病例。在长QT间期患者中,低钾血症以及进一步延迟复极化的药物可能促使危及生命的心律失常发生。