The Past, Present, and Future of Off-Pump Coronary Artery Bypass Grafting.

The evolution of treatment for ischemic heart disease has been driven by advancements in both diagnostic and therapeutic methods, including coronary angiography, percutaneous coronary intervention (PCI), and coronary artery bypass grafting (CABG). Initially, CABG relied on on-pump techniques using saphenous vein grafts; however, off-pump coronary artery bypass grafting (OPCAB) emerged as an alternative to reduce complications associated with cardiopulmonary bypass. Despite potential benefits-such as a reduced risk of stroke, shorter hospital stays, and fewer respiratory and renal complications-OPCAB has seen limited adoption, particularly in Western countries, owing to its technical demands and concerns regarding graft patency and complete revascularization. Large-scale randomized trials have reported mixed results, with outcomes strongly influenced by surgeon experience and patient selection. In contrast, smaller studies by experienced surgeons have demonstrated comparable graft patency and superior outcomes in high-risk patients. Recent meta-analyses underscore the need for total arterial revascularization and no-touch aortic techniques to further optimize OPCAB results, particularly in high-risk populations. Moving forward, OPCAB shows significant promise for patients with severe comorbidities, such as those with calcified aortas or poor ventricular function. Enhanced training programs and hybrid revascularization strategies that integrate minimally invasive CABG with PCI could further expand OPCAB adoption. By leveraging its unique strengths-including reduced postoperative complications and improved outcomes for high-risk patients-OPCAB could play a pivotal role in modern cardiac surgery. To remain competitive with PCI, surgeons must actively prepare for OPCAB by developing expertise in both techniques tailored to the patient's clinical condition.