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育龄期女性子宫黏液样平滑肌肉瘤:一例报告

Myxoid leiomyosarcoma of the uterus in a woman of childbearing age: A case report.

作者信息

Wang Tingting, Wang Xiaoqin, Wu Jun, Li Xin, Peng Lina

机构信息

Department of Gynecology, Women and Children's Hospital Affiliated to Ningbo University, Ningbo, Zhejiang 315000, P.R. China.

Department of Imaging, Women and Children's Hospital Affiliated to Ningbo University, Ningbo, Zhejiang 315000, P.R. China.

出版信息

Oncol Lett. 2025 Apr 2;29(6):264. doi: 10.3892/ol.2025.15010. eCollection 2025 Jun.

Abstract

Myxoid leiomyosarcoma of the uterus (MLMS) is an extremely rare malignancy characterized by a poor prognosis. The present report describes a rare case of MLMS in a woman of childbearing age. The patient was a 33-year-old woman who presented with lower abdominal pain and was initially diagnosed with uterine myoma by preoperative B-mode ultrasound and magnetic resonance imaging. However, intraoperative pathological biopsy indicated the presence of a malignant tumor. The patient underwent total uterine and bilateral salpingectomy, along with pelvic lymph node biopsy, which confirmed the diagnosis of MLMS postoperatively. In a subsequent surgical procedure, the bilateral ovaries, omentum and appendix were also resected. The patient then received chemotherapy with gemcitabine and docetaxel and remains in good health, with no signs of recurrence. The present case report underscores the importance of early diagnosis and personalized treatment strategies for MLMS, particularly regarding their implications for fertility and survival outcomes in young women.

摘要

子宫黏液样平滑肌肉瘤(MLMS)是一种极为罕见的恶性肿瘤,预后较差。本报告描述了一例育龄期女性的罕见MLMS病例。患者为一名33岁女性,表现为下腹部疼痛,术前经B超和磁共振成像初步诊断为子宫肌瘤。然而,术中病理活检显示存在恶性肿瘤。患者接受了全子宫及双侧输卵管切除术,以及盆腔淋巴结活检,术后确诊为MLMS。在随后的手术中,双侧卵巢、大网膜和阑尾也被切除。患者随后接受了吉西他滨和多西他赛化疗,目前身体健康,无复发迹象。本病例报告强调了MLMS早期诊断和个性化治疗策略的重要性,特别是其对年轻女性生育能力和生存结局的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7090/11995690/048800ecb9a5/ol-29-06-15010-g00.jpg

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