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急性胰腺炎相关的信号通路

Signaling Pathways Involved in Acute Pancreatitis.

作者信息

Luo Mengchen, Jin Ting, Fang Yi, Chen Feng, Zhu Lujian, Bai Jin, Ding Jin

机构信息

Department of Gastroenterology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, People's Republic of China.

Department of Infectious Diseases, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, People's Republic of China.

出版信息

J Inflamm Res. 2025 Feb 17;18:2287-2303. doi: 10.2147/JIR.S485804. eCollection 2025.

DOI:10.2147/JIR.S485804
PMID:40230438
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11995411/
Abstract

Acute pancreatitis (AP) is a common digestive emergency with high morbidity and mortality. Over the past decade, significant progress has been made in understanding the mechanisms of AP, including oxidative stress, disruptions in calcium homeostasis, endoplasmic reticulum stress, inflammatory responses, and various forms of cell death. This review provides an overview of the typical signaling pathways involved and proposes the latest clinical translation prospects. These strategies are important for the early management of AP, preventing multi-organ injury, and improving the overall prognosis of the disease.

摘要

急性胰腺炎（AP）是一种常见的消化系统急症，发病率和死亡率都很高。在过去十年中，人们对AP的发病机制有了重大进展，包括氧化应激、钙稳态破坏、内质网应激、炎症反应以及各种形式的细胞死亡。本文综述了相关的典型信号通路，并提出了最新的临床转化前景。这些策略对于AP的早期管理、预防多器官损伤以及改善疾病的总体预后都很重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/400b/11995411/90909f1eedc6/JIR-18-2287-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/400b/11995411/32be10e1c2b7/JIR-18-2287-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/400b/11995411/6b26dba39f50/JIR-18-2287-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/400b/11995411/90909f1eedc6/JIR-18-2287-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/400b/11995411/32be10e1c2b7/JIR-18-2287-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/400b/11995411/6b26dba39f50/JIR-18-2287-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/400b/11995411/90909f1eedc6/JIR-18-2287-g0003.jpg

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本文引用的文献

1
Ca2+ tunneling architecture and function are important for secretion.钙离子通道结构与功能对于分泌非常重要。
J Cell Biol. 2025 Jan 6;224(1). doi: 10.1083/jcb.202402107. Epub 2024 Nov 5.
2
STAT3 Increases CVB3 Replication and Acute Pancreatitis and Myocarditis Pathology via Impeding Nuclear Translocation of STAT1 and Interferon-Stimulated Gene Expression.STAT3 通过阻碍 STAT1 的核转位和干扰素刺激基因表达增加 CVB3 复制和急性胰腺炎及心肌炎病理。
Int J Mol Sci. 2024 Aug 19;25(16):9007. doi: 10.3390/ijms25169007.
3
Irisin Ameliorate Acute Pancreatitis and Acinar Cell Viability through Modulation of the Unfolded Protein Response (UPR) and PPARγ-PGC1α-FNDC5 Pathways.
鸢尾素通过调节未折叠蛋白反应 (UPR) 和 PPARγ-PGC1α-FNDC5 途径改善急性胰腺炎和胰腺腺泡细胞活力。
Biomolecules. 2024 May 30;14(6):643. doi: 10.3390/biom14060643.
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The role of Interleukin-22 in severe acute pancreatitis.白细胞介素-22 在重症急性胰腺炎中的作用。
Mol Med. 2024 May 15;30(1):60. doi: 10.1186/s10020-024-00826-7.
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NF-κB in biology and targeted therapy: new insights and translational implications.生物学与靶向治疗中的核因子-κB：新见解与转化意义
Signal Transduct Target Ther. 2024 Mar 4;9(1):53. doi: 10.1038/s41392-024-01757-9.
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Reactive oxygen species and cell signaling. Review.活性氧与细胞信号传导。综述。
Biochim Biophys Acta Mol Cell Res. 2024 Feb;1871(2):119573. doi: 10.1016/j.bbamcr.2023.119573. Epub 2023 Nov 8.
7
Endoplasmic Reticulum Stress Promotes the Expression of TNF-α in THP-1 Cells by Mechanisms Involving ROS/CHOP/HIF-1α and MAPK/NF-κB Pathways.内质网应激通过 ROS/CHOP/HIF-1α 和 MAPK/NF-κB 通路促进 THP-1 细胞 TNF-α 的表达。
Int J Mol Sci. 2023 Oct 14;24(20):15186. doi: 10.3390/ijms242015186.
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Mitochondrial dysfunction promotes the transition of precursor to terminally exhausted T cells through HIF-1α-mediated glycolytic reprogramming.线粒体功能障碍通过 HIF-1α 介导的糖酵解重编程促进前体细胞向终末耗竭 T 细胞的转化。
Nat Commun. 2023 Oct 27;14(1):6858. doi: 10.1038/s41467-023-42634-3.
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