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猫慢性龈口炎:相关因素的全面系统综述

Feline chronic gingivostomatitis: a thorough systematic review of associated factors.

作者信息

Sánchez-Vallejo Mauricio, Vélez-Velásquez Paula, Correa-Valencia Nathalia M

机构信息

CENTAURO Research Group, School of Veterinary Medicine, Faculty of Agricultural Sciences, Universidad de Antioquia, Medellín, Colombia.

School of Veterinary Medicine, Faculty of Agricultural Sciences, Universidad de Antioquia, Medellín, Colombia.

出版信息

J Feline Med Surg. 2025 Apr;27(4):1098612X241310590. doi: 10.1177/1098612X241310590. Epub 2025 Apr 15.

Abstract

ObjectivesThe aim of the present study was to systematically compile and analyze the available evidence from studies that have explored factors associated with feline chronic gingivostomatitis (FCGS).MethodsAn electronic search was conducted using four databases (OVID/MEDLINE, PubMed, SciELO, Redalyc), as well as proceedings from the European Veterinary Dentistry Forum and the Veterinary Dental Forum, when available. The inclusion and exclusion criteria were predetermined and maintained throughout the systematic process, focusing exclusively on articles published in peer-reviewed journals.ResultsA total of 17 articles met the definitive inclusion criteria. All were published in English, in 11 journals, and between 1984 and 2023. The relevant articles reported a global frequency of FCGS of 10.9% (747/6881 cats). Six studies reported the exploration of factors inherent to the cat (eg, age, sex, reproductive status), two reported the exploration of factors related to the cats' environment, feeding and management (eg, type of confinement, number of cats in the household, vaccination status) and 15 reported the exploration of factors related to infectious agents (eg, feline calicivirus [FCV], feline leukemia virus [FeLV], feline herpesvirus type 1 [FHV-1], species, subspecies ) and microbiome profiling.Conclusions and relevanceAlthough the specific etiology of FCGS remains unknown, factors involved in the disease suggest that oral microbiome dysbiosis and the presence of infectious agents such as , species and , as well as FCV and FHV-1, play crucial roles in its pathogenesis. In addition, factors involving the cat's immune status, including coinfection with feline immunodeficiency virus and FeLV, have been associated with an increased risk of developing FCGS. Microbial dysbiosis and the alteration of local and systemic immune responses emerge as key elements that perpetuate chronic inflammation. Furthermore, the relationship with non-infectious factors must be considered to understand the complex origin of the disease.

摘要

目的

本研究的目的是系统地收集和分析已探索与猫慢性龈口炎(FCGS)相关因素的研究中的现有证据。

方法

使用四个数据库(OVID/MEDLINE、PubMed、SciELO、Redalyc)进行电子检索,并在有相关内容时检索欧洲兽医牙科学论坛和兽医牙科学论坛的会议记录。纳入和排除标准在整个系统过程中预先确定并保持不变,仅关注发表在同行评审期刊上的文章。

结果

共有17篇文章符合最终纳入标准。所有文章均以英文发表,发表于11种期刊,发表时间在1984年至2023年之间。相关文章报告FCGS的全球发生率为10.9%(747/6881只猫)。六项研究报告了对猫固有因素(如年龄、性别、生殖状态)的探索,两项报告了对猫的环境、喂养和管理相关因素(如饲养类型、家庭猫数量、疫苗接种状况)的探索,15项报告了对感染因子(如猫杯状病毒[FCV]、猫白血病病毒[FeLV]、猫疱疹病毒1型[FHV-1]、物种、亚种)和微生物组分析相关因素的探索。

结论及意义

尽管FCGS的具体病因尚不清楚,但该疾病涉及的因素表明,口腔微生物群失调以及诸如[具体物种未明确写出]物种和[具体物种未明确写出]等感染因子的存在,以及FCV和FHV-1,在其发病机制中起关键作用。此外,涉及猫免疫状态的因素,包括与猫免疫缺陷病毒和FeLV的合并感染,与发生FCGS的风险增加有关。微生物失调以及局部和全身免疫反应的改变是使慢性炎症持续存在的关键因素。此外,必须考虑与非感染性因素的关系,以了解该疾病的复杂起源。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6479/12035028/1a72d0f6df70/10.1177_1098612X241310590-fig1.jpg

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