糖基转移酶是免疫球蛋白的进化前身吗？

Are glycosyltransferases the evolutionary antecedents of the immunoglobulins?

作者信息

Roth S

出版信息

Q Rev Biol. 1985 Jun;60(2):145-53. doi: 10.1086/414313.

Abstract

The glycosyltransferases may be the evolutionary precursors of the immunoglobulins, although critical evidence for this hypothesis is not yet available. The transferases add sugars to non-glycosylated proteins, lipids, and organic molecules, as well as to oligosaccharides, glycoproteins, and glycolipids. The enzymes are specific, extremely polymorphic, occasionally inducible, and may be structurally related to one another. Circumstantial evidence links the transferases to both the MHC and T/t loci in the mouse. Finally, antibodies against purified transferases are difficult to produce and sometimes they react with immunoglobulins. The present hypothesis predicts that transferases should show some sequence homology with immunoglobulins, and that some MHC proteins will be glycosyltransferases.

摘要

糖基转移酶可能是免疫球蛋白的进化前体，尽管这一假说的关键证据尚未可得。这些转移酶可将糖类添加到非糖基化的蛋白质、脂质和有机分子上，也可添加到寡糖、糖蛋白和糖脂上。这些酶具有特异性、高度多态性、偶尔可诱导，且在结构上可能彼此相关。间接证据将这些转移酶与小鼠的主要组织相容性复合体（MHC）和T/t基因座联系起来。最后，针对纯化转移酶的抗体很难制备，且有时会与免疫球蛋白发生反应。目前的假说预测，转移酶应与免疫球蛋白表现出一定的序列同源性，且某些MHC蛋白将是糖基转移酶。