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特级初榨橄榄油减轻坏死性小肠结肠炎中的肺损伤：对新生大鼠模型中转化生长因子β1、半胱天冬酶-3和丙二醛的影响。

Extra virgin olive oil mitigates lung injury in necrotizing enterocolitis: Effects on TGFβ1, Caspase-3, and MDA in a neonatal rat model.

作者信息

Tuşat Mustafa, Eröz Recep, Bölükbaş Ferhan, Özkan Erkan, Demirtaş Mehmet Semih, Erdal Hüseyin, Özocak Osman Okan

机构信息

Aksaray University Medical Faculty, Department of Pediatric Surgery, Aksaray University, Aksaray, Turkey.

Aksaray University Medical Faculty, Department of Medical Genetics, Aksaray University, Aksaray, Turkey.

出版信息

PLoS One. 2025 Apr 15;20(4):e0320938. doi: 10.1371/journal.pone.0320938. eCollection 2025.

DOI:10.1371/journal.pone.0320938
PMID:40233022
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11999148/
Abstract

BACKGROUND: Necrotizing enterocolitis (NE), which is common in premature babies, has been associated with lung damage. Our aim is to explore the effect of enterally administered extra virgin olive oil (EO) with rich polyphenol content on clinical parameters, histopathological score, Transforming growt factor beta-1 (TGFβ1), Caspase 3 and Malondialdehyde (MDA) levels in NE-related lung injury of neonatal rats. METHODS: Three groups (control, NE, NE+EO) were created, with 8 neonatal rats in each group. NE was induced by hypoxia-hyperoxia-hypothermia and formula feeding. EO was given to the treatment group by orogastric probe for 3 days. Intestinal and lung tissue were excised for analysis. RESULTS: TGFβ1 expression levels, TGFβ1 and MDA concentration levels were higher in the NE compared to NE +  EO and control groups (p < 0.001), and their levels decreased after EO treatment compared to the NE group (p < 0.001). It was determined that EO treatment significantly reduced the histopathological damage and the caspase-3 (CASP3) expression level in the lung (p < 0.001). CONCLUSION: Our findings emphasize that TGFß1 has an crucial function in NE-related lung injury and that EO has therapeutic potential in NE-related lung injury.

摘要

背景：坏死性小肠结肠炎（NE）在早产儿中很常见，且与肺损伤有关。我们的目的是探讨经肠道给予富含多酚的特级初榨橄榄油（EO）对新生大鼠NE相关肺损伤的临床参数、组织病理学评分、转化生长因子β-1（TGFβ1）、半胱天冬酶3和丙二醛（MDA）水平的影响。 方法：创建三组（对照组、NE组、NE+EO组），每组8只新生大鼠。通过缺氧-高氧-低温及配方奶喂养诱导NE。治疗组通过胃管给予EO，持续3天。切除肠道和肺组织进行分析。 结果：与NE+EO组和对照组相比，NE组中TGFβ1表达水平、TGFβ1和MDA浓度水平更高（p<0.001），与NE组相比，EO治疗后其水平降低（p<0.001）。确定EO治疗可显著减轻肺组织病理学损伤和半胱天冬酶-3（CASP3）表达水平（p<0.001）。 结论：我们的研究结果强调TGFβ1在NE相关肺损伤中起关键作用，且EO在NE相关肺损伤中具有治疗潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/005f/11999148/b531c3b1aabe/pone.0320938.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/005f/11999148/3a6501df87d9/pone.0320938.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/005f/11999148/932ad3304b23/pone.0320938.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/005f/11999148/29be18631147/pone.0320938.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/005f/11999148/dcd05a712769/pone.0320938.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/005f/11999148/1d78d184c933/pone.0320938.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/005f/11999148/b531c3b1aabe/pone.0320938.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/005f/11999148/3a6501df87d9/pone.0320938.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/005f/11999148/932ad3304b23/pone.0320938.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/005f/11999148/29be18631147/pone.0320938.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/005f/11999148/dcd05a712769/pone.0320938.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/005f/11999148/1d78d184c933/pone.0320938.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/005f/11999148/b531c3b1aabe/pone.0320938.g006.jpg

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[3]
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[4]
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[6]
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[7]
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[8]
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[9]
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