Dong Siyuan, Wang Xudong, Liu Yixin, Qiao Lu, Xue Qiong, Zhou Yixin, Xu Zhao, Chen Qun, Chen Chen, Liu Na, Wang Jinhai
Xi'an Jiaotong University Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi province, P.R. China.
College of Safety Science and Engineering, Xi`an University of Science and Technology, Xi'an, Shaanxi province, P.R. China.
PLoS One. 2025 Apr 15;20(4):e0319096. doi: 10.1371/journal.pone.0319096. eCollection 2025.
Gastric ulcer animal models are essential for research, but conventional acetic acid-based methods are limited by technical complexity, prolonged modeling duration, and poor applicability for solid anti-ulcer drug testing. This study described a novel and simplified method for inducing gastric ulcers in rats using filter paper imbued with acetic acid. The method provided consistent ulcer formation with uniform size and shape, allowing for targeted drug efficacy testing. Results indicated that the 75% acetic acid concentration yielded the most clinically relevant gastric ulcer model, completed ulcer forming within a day and healing visible after seven days. In conclusion, this model closely replicates human gastric ulcers and is well-suited for preclinical testing of anti-ulcer drugs.
胃溃疡动物模型对研究至关重要，但传统的基于乙酸的方法受到技术复杂性、建模时间长以及对固体抗溃疡药物测试适用性差的限制。本研究描述了一种使用浸有乙酸的滤纸在大鼠中诱导胃溃疡的新颖且简化的方法。该方法能产生大小和形状一致的溃疡，便于进行靶向药物疗效测试。结果表明，75%的乙酸浓度产生的胃溃疡模型与临床最为相关，一天内完成溃疡形成，七天后可见愈合。总之，该模型能紧密复制人类胃溃疡，非常适合抗溃疡药物的临床前测试。
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