体内和体外苯丙胺对小鼠纹状体突触体多巴胺摄取的比较。
A comparison of in vivo and in vitro amphetamine on the synaptosomal uptake of dopamine in mouse striatum.
作者信息
Hadfield M G
出版信息
Res Commun Chem Pathol Pharmacol. 1985 May;48(2):183-8.
PMID:4023407
Abstract
Amphetamine (AMPH) produced competitive uptake inhibition of 3H-dopamine (DA) in synaptosomes obtained from mouse striatum--whether it was injected beforehand into living animals or simply added to the incubation medium. However, the in vivo drug doses required to produce this effect were high (ED50 = 65 mg/kg.) as compared with the in vitro doses (ED50 = 2.5 X 10(-6) M).
摘要
无论是预先将苯丙胺（AMPH）注射到活体动物体内，还是简单地添加到孵育培养基中，它都会对从小鼠纹状体获得的突触体中的3H-多巴胺（DA）产生竞争性摄取抑制作用。然而，与体外剂量（ED50 = 2.5×10（-6）M）相比，产生这种效应所需的体内药物剂量很高（ED50 = 65 mg/kg）。
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