Siu P M, Vick J A
Res Commun Chem Pathol Pharmacol. 1985 May;48(2):203-8.
1-(2-Methyl-3-hydroxy-5-hydroxymethyl-4-pyridyl)-6,7-dihydroxy-1,2, 3,4-tetrahydroisoquinoline (PTIQ) when injected into anesthetized normotensive minipigs and dogs lowers the arterial blood pressure in a dose-related manner. The blood pressure lowering effect of PTIQ is greater on minipigs than dogs at comparable dose levels. The heart rate is generally slower after PTIQ was injected than the control.
1-(2-甲基-3-羟基-5-羟甲基-4-吡啶基)-6,7-二羟基-1,2,3,4-四氢异喹啉（PTIQ）注射到麻醉的正常血压小型猪和犬体内时，会以剂量相关的方式降低动脉血压。在相当的剂量水平下，PTIQ对小型猪的降压作用比对犬的更强。注射PTIQ后，心率通常比对照组慢。
