Hwang In Cheol, Ahn Hong Yup, Park Yujin
Department of Family Medicine, Gil Medical Centre, Gachon University College of Medicine, Incheon, Korea.
Department of Statistics, Dongguk University, Seoul, Korea.
J Coll Physicians Surg Pak. 2025 Apr;35(4):536-538. doi: 10.29271/jcpsp.2025.04.536.
Studies of C-reactive protein (CRP) levels and suicidal behaviours have shown inconsistent results previously. This study investigated the relationship between CRP levels and suicidal ideation in a large population-based cohort in Korea to enhance the understanding of the biological aspects of suicide and inform more accurate risk assessment models in clinical applications. A multivariate regression model was used to estimate the CRP levels by suicidal ideation and calculate the odds ratio (OR) for suicidal ideation per increase in CRP. People with suicidal ideation had higher CRP levels than those without suicidal ideation (1.35 mg/dL vs. 1.17 mg/dL). In the age- and gender-adjusted model, the OR for suicidal ideation per 1-SD increase in log (CRP) was 1.14 (p = 0.029). However, the fully adjusted model did not reach statistical significance. The relationship between CRP levels and suicide might not be evident among Korean adults. Key Words: C-reactive protein, Inflammation, Socioeconomic factors, Suicidal ideation, Public health problem.
先前关于C反应蛋白（CRP）水平与自杀行为的研究结果并不一致。本研究调查了韩国一个大型人群队列中CRP水平与自杀意念之间的关系，以增进对自杀生物学方面的理解，并为临床应用中更准确的风险评估模型提供依据。采用多元回归模型按自杀意念估计CRP水平，并计算CRP每升高一个单位时自杀意念的比值比（OR）。有自杀意念的人CRP水平高于无自杀意念的人（1.35mg/dL对1.17mg/dL）。在年龄和性别调整模型中，log(CRP)每增加1个标准差时自杀意念的OR为1.14（p=0.029）。然而，完全调整模型未达到统计学显著性。在韩国成年人中，CRP水平与自杀之间的关系可能不明显。关键词：C反应蛋白、炎症、社会经济因素、自杀意念、公共卫生问题。
