Piana L, Conte M, Padaut J P, Delpero J R, Roux G, Franquebalme J P
Rev Fr Gynecol Obstet. 1985 May;80(6):353-9.
No results from therapeutic trials describing the best therapeutic procedure for cervical carcinoma in stages I and IIa are available. Analysis of a series of 242 cases of cervical carcinoma in stages I and IIa, from 1975 to 1980, treated with radical surgery and radiation therapy, yields a therapeutic approach that envisions the most reliable evaluation of subclinical extension, cure of cervical tumor and prevention of pelvic or extra-pelvic metastases with a minimum of post-radiation problems. The choice of combination surgery and radiation therapy is primarily determined by staging and the volume of the central pelvic tumor. For stages I and IIb (upper third of vagina involved) with central pelvic tumor less than 4 cm in diameter, the usual procedure is recommended i.e. radium application, total hysterectomy with pelvic lymphadenectomy followed by external irradiation of pelvic lymphatics in cases with lymphadenopathy. For stages IIb (obvious parametrial involvement) and for stages I or II with central pelvic tumor between 4 and 6 cm in diameter: total dose external and internal pelvic radiation therapy followed by total hysterectomy without pelvic lymphadenectomy but with exploration of obturator, hypogastric, external iliac, common iliac, and aortic nodes. For the rare supravaginal central pelvic tumors greater than 6 cm in diameter, the risk of clinical evaluative error and incomplete sterility by irradiation alone, warrants first an explorative laparotomy using Wertheim's procedure, then pelvic lymphadenectomy and exploration of pelvic and aortic lymph nodes.
目前尚无关于描述I期和IIa期宫颈癌最佳治疗方法的治疗试验结果。对1975年至1980年间接受根治性手术和放射治疗的242例I期和IIa期宫颈癌病例进行分析,得出了一种治疗方法,该方法旨在以最少的放疗后问题对亚临床扩散进行最可靠的评估、治愈宫颈肿瘤并预防盆腔或盆腔外转移。联合手术和放射治疗的选择主要取决于分期和盆腔中央肿瘤的大小。对于I期和IIb期(累及阴道上三分之一)且盆腔中央肿瘤直径小于4cm的患者,推荐常规治疗方法,即敷贴镭,行全子宫切除术加盆腔淋巴结清扫术,若有淋巴结病则随后对盆腔淋巴管进行外照射。对于IIb期(明显宫旁受累)以及I期或II期且盆腔中央肿瘤直径在4至6cm之间的患者:先行盆腔内外照射治疗,然后行全子宫切除术,不进行盆腔淋巴结清扫,但需探查闭孔、腹下、髂外、髂总及主动脉旁淋巴结。对于罕见的直径大于6cm的阴道上中央盆腔肿瘤,仅通过放疗存在临床评估错误和不育不完全的风险,因此首先应采用韦特海姆手术进行剖腹探查,然后进行盆腔淋巴结清扫及盆腔和主动脉旁淋巴结探查。