Ding Sheng, Wang Zaibao, Li Chunliu, Wang Guizhi, Li Juan, Zhu Hongrui, He Keqiang
Graduate School of Bengbu Medical University, Bengbu, People's Republic of China.
Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, People's Republic of China.
Drug Des Devel Ther. 2025 Apr 11;19:2767-2777. doi: 10.2147/DDDT.S501222. eCollection 2025.
Propofol is widely used for general anesthesia in elderly patients. Fospropofol disodium, a precursor of propofol, may reduce the incidence of postoperative nausea and vomiting (PONV). However, the effects of these two drugs on patients' postoperative recovery quality are unclear. The present study aimed to evaluate the effects of the two drugs on postoperative recovery quality in elderly patients who underwent total hip arthroplasty.
We retrospectively analyzed 168 patients from the First Affiliated Hospital of USTC from October 2022 to June 2024. These individuals were assigned to fospropofol disodium group (F) or propofol group (P) according to the patients' anesthesia induction and maintenance medication. The primary outcome was the rate of occurrence of PONV. The secondary outcomes included the time of extubation and the time of stay in post-anesthesia care unit (PACU), hospital length of stay, perioperative hemodynamic data and patients' liver and renal functions.
PONV occurred to be lesser in group F than in group P (15.94% vs 33.33%, P < 0.05). Group P spent less in the extubation time (25.71 vs 33.36 min, P < 0.05) and PACU stay length (62.61 vs 65.65 min, P > 0.05), but hospital length of stay is longer (6.24 vs 5.8 days, P > 0.05). Liver and renal functions indexes and hemodynamic data between the 2 groups were similar (P > 0.05). The type of drug was a factor affecting the time of extubation. The type of drug and the patient's gender were influential factors in the incidence of PONV.
Fospropofol disodium reduces the incidence of PONV in patients. And the effects of fospropofol disodium on postoperative recovery quality are similar to that of propofol in older patients who underwent total hip arthroplasty.
丙泊酚广泛用于老年患者的全身麻醉。丙泊酚二钠，作为丙泊酚的前体药物，可能会降低术后恶心呕吐（PONV）的发生率。然而，这两种药物对患者术后恢复质量的影响尚不清楚。本研究旨在评估这两种药物对接受全髋关节置换术的老年患者术后恢复质量的影响。
我们回顾性分析了2022年10月至2024年6月期间来自中国科学技术大学附属第一医院的168例患者。根据患者的麻醉诱导和维持用药情况，将这些患者分为丙泊酚二钠组（F组）和丙泊酚组（P组）。主要结局指标为PONV的发生率。次要结局指标包括拔管时间、在麻醉后监护病房（PACU）的停留时间、住院时间、围手术期血流动力学数据以及患者的肝肾功能。
F组的PONV发生率低于P组（15.94%对33.33%，P<0.05）。P组的拔管时间较短（25.71对33.36分钟，P<0.05），在PACU的停留时间也较短（62.61对65.65分钟，P>0.05），但住院时间较长（6.24对5.8天，P>0.05）。两组之间的肝肾功能指标和血流动力学数据相似（P>0.05）。药物类型是影响拔管时间的一个因素。药物类型和患者性别是PONV发生率的影响因素。
丙泊酚二钠可降低患者PONV的发生率。在接受全髋关节置换术的老年患者中，丙泊酚二钠对术后恢复质量的影响与丙泊酚相似。
