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Clin Case Rep. 2025 Apr 15;13(4):e70429. doi: 10.1002/ccr3.70429. eCollection 2025 Apr.
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J Med Case Rep. 2019 Jun 19;13(1):186. doi: 10.1186/s13256-019-2130-8.
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Case report: A case of fulminant type 1 diabetes mellitus after COVID-19 vaccination during treatment of advanced gastric cancer: pitfall in managing immune-related adverse events.病例报告：1例晚期胃癌治疗期间接种新冠疫苗后发生的暴发性1型糖尿病：免疫相关不良事件管理中的陷阱
Front Oncol. 2023 Dec 20;13:1264281. doi: 10.3389/fonc.2023.1264281. eCollection 2023.
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A case report of fulminant type 1 diabetes mellitus associated with drug-induced hypersensitivity syndrome in an elderly patient with coxsackie B4 virus infection and human leukocyte antigen-A24 haplotype.一名老年患者患暴发性1型糖尿病，伴有柯萨奇B4病毒感染及人类白细胞抗原-A24单倍型，并发药物性超敏反应综合征的病例报告。
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本文引用的文献

1
Case report: A case of fulminant type 1 diabetes mellitus after COVID-19 vaccination during treatment of advanced gastric cancer: pitfall in managing immune-related adverse events.病例报告：1例晚期胃癌治疗期间接种新冠疫苗后发生的暴发性1型糖尿病：免疫相关不良事件管理中的陷阱
Front Oncol. 2023 Dec 20;13:1264281. doi: 10.3389/fonc.2023.1264281. eCollection 2023.
2
COVID-19 Vaccination Prior to SARS-CoV-2 Infection Reduced Risk of Subsequent Diabetes Mellitus: A Real-World Investigation Using U.S. Electronic Health Records.COVID-19 疫苗接种可降低 SARS-CoV-2 感染后继发糖尿病的风险：利用美国电子健康记录进行的真实世界研究。
Diabetes Care. 2023 Dec 1;46(12):2193-2200. doi: 10.2337/dc23-0936.
3
Anti-GAD antibody-positive fulminant type 1 diabetes developed following SARS-CoV-2 vaccination.接种新型冠状病毒2型疫苗后出现抗谷氨酸脱羧酶抗体阳性暴发性1型糖尿病。
Diabetol Int. 2023 Jul 31;14(4):422-426. doi: 10.1007/s13340-023-00648-8. eCollection 2023 Oct.
4
Incidence of diabetes following COVID-19 vaccination and SARS-CoV-2 infection in Hong Kong: A population-based cohort study.香港 COVID-19 疫苗接种和 SARS-CoV-2 感染后糖尿病的发病率：一项基于人群的队列研究。
PLoS Med. 2023 Jul 24;20(7):e1004274. doi: 10.1371/journal.pmed.1004274. eCollection 2023 Jul.
5
New-Onset Fulminant Type 1 Diabetes Following SARS-CoV-2 Protein Subunit Vaccine: A Case Report and Literature Review.新型冠状病毒蛋白亚单位疫苗接种后新发暴发性 1 型糖尿病：病例报告及文献复习。
J Korean Med Sci. 2023 Jun 19;38(24):e209. doi: 10.3346/jkms.2023.38.e209.
6
Graves' Disease after mRNA COVID-19 Vaccination, with the Presence of Autoimmune Antibodies Even One Year Later.mRNA新冠疫苗接种后发生的格雷夫斯病，甚至在一年后仍存在自身免疫抗体。
Vaccines (Basel). 2023 May 3;11(5):934. doi: 10.3390/vaccines11050934.
7
Coxsackievirus and Type 1 Diabetes: Diabetogenic Mechanisms and Implications for Prevention.柯萨奇病毒与 1 型糖尿病：致糖尿病机制及预防意义。
Endocr Rev. 2023 Jul 11;44(4):737-751. doi: 10.1210/endrev/bnad007.
8
Autoimmune hepatitis after COVID-19 vaccination.接种 COVID-19 疫苗后的自身免疫性肝炎。
Front Immunol. 2022 Nov 25;13:1035073. doi: 10.3389/fimmu.2022.1035073. eCollection 2022.
9
Fulminant Type 1 Diabetes Mellitus after SARS-CoV-2 Vaccination: A Case Report.新型冠状病毒疫苗接种后暴发性1型糖尿病：一例报告
Vaccines (Basel). 2022 Nov 11;10(11):1905. doi: 10.3390/vaccines10111905.
10
New-onset atypical fulminant type 1 diabetes after COVID-19 vaccination: A case report.新冠病毒疫苗接种后新发非典型暴发性 1 型糖尿病：一例报告
Clin Case Rep. 2022 Oct 17;10(10):e6473. doi: 10.1002/ccr3.6473. eCollection 2022 Oct.

伴有柯萨奇病毒B6抗体升高和基于RNA的COVID-19疫苗接种的暴发性1型糖尿病：一例报告及文献复习

Fulminant Type 1 Diabetes Mellitus With Concomitant Coxsackievirus B6 Antibody Elevation and RNA-Based COVID-19 Vaccination: A Case Report and Review of the Literature.

作者信息

Minami Hisaka, Furukawa Shinya, Miyake Teruki, Kurokawa Keisho, Sasaki Yasuhiro, Nakaishi Masayuki, Nagamatsu Kensuke, Yamago Hiroka, Shibata Naozumi, Hiasa Yoichi, Matsuura Bunzo

机构信息

Department of Internal Medicine Ehime Prefectural Niihama Hospital Niihama Ehime Japan.

Health Services Center Ehime University Matsuyama Ehime Japan.

出版信息

Clin Case Rep. 2025 Apr 15;13(4):e70429. doi: 10.1002/ccr3.70429. eCollection 2025 Apr.

DOI:10.1002/ccr3.70429
PMID:40236311
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11997456/
Abstract

Fulminant type 1 diabetes is a rare but severe condition that can develop rapidly, often in association with viral infections. In this case, coxsackievirus B6 antibody levels were elevated after disease onset, though its significance remains unclear. This highlights the importance of thorough viral screening in fulminant type 1 diabetes and the need for further research to better understand potential contributing factors, including in post-vaccination contexts.

摘要

暴发性1型糖尿病是一种罕见但严重的疾病，通常与病毒感染相关，起病迅速。在该病例中，柯萨奇病毒B6抗体水平在发病后升高，但其意义尚不清楚。这凸显了在暴发性1型糖尿病中进行全面病毒筛查的重要性，以及进一步开展研究以更好地了解潜在促成因素的必要性，包括疫苗接种后的情况。