Miller Alex J, Ovrom Erik A, Zaremba Solomiia, Senefeld Jonathon W, Wiggins Chad C, Dominelli Paolo B, Ripoll Juan G, Welch Brian T, Joyner Michael J, Ramsook Andrew H
Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Alix School of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
medRxiv. 2025 Apr 6:2025.04.04.25324181. doi: 10.1101/2025.04.04.25324181.
Interstitial lung disease (ILD) encompasses multiple pulmonary disorders characterized by damaged pulmonary tissue caused by a sequence of inflammation and fibrosis. While much is known about ILD-associated changes within the parenchyma and the pathophysiological processes underpinning the disruption of pulmonary dynamics and gas exchange, less is known about ILD-associated changes of luminal area within the large conducting airways. We aimed to investigate whether luminal area of the large conducting airways is different between patients with ILD and healthy controls. In a retrospective case-control study, luminal areas of seven large conducting airways were measured using three-dimensional reconstructions of computed tomography imaging. Patients with ILD (N=82; 54% female) were compared to control subjects matched for age, sex, and height. Univariate ANOVA tests or Kruskal-Wallis tests were used to analyze group and sex differences. Patients with ILD had greater large conducting airway luminal areas than control subjects for measured large conducting airways, including the trachea (296±73 vs. 247±65 mm, <0.001), right main bronchus (214±59 vs. 161±46 mm, <0.001), bronchus intermediate (123±32 vs. 94±28 mm, <0.001), right upper lobe (81±22 vs. 61±20 mm, <0.001), left main bronchus (151±41 vs. 119±35 mm, <0.001), left lower lobe (71±22 vs. 48±15 mm, <0.001), and left upper lobe (86±21 vs. 68±22 mm, <0.001). Among patients with ILD, males had 17-34% greater luminal areas (normalized to height) than females depending on the airway segment (all <0.05).
间质性肺疾病（ILD）包括多种肺部疾病，其特征是由一系列炎症和纤维化导致肺组织受损。虽然我们对ILD相关的实质内变化以及支撑肺动力学和气体交换破坏的病理生理过程了解很多，但对大传导气道管腔面积的ILD相关变化了解较少。我们旨在研究ILD患者与健康对照者之间大传导气道的管腔面积是否存在差异。在一项回顾性病例对照研究中，使用计算机断层扫描成像的三维重建测量了7个大传导气道的管腔面积。将ILD患者（N = 82；54%为女性）与年龄、性别和身高匹配的对照受试者进行比较。使用单因素方差分析或克鲁斯卡尔 - 沃利斯检验来分析组间和性别差异。对于所测量的大传导气道，包括气管（296±73 vs. 247±65 mm，<0.001）、右主支气管（214±59 vs. 161±46 mm，<0.001）、中间支气管（123±32 vs. 94±28 mm，<0.001）、右上叶（81±22 vs. 61±20 mm，<0.001）、左主支气管（151±41 vs. 119±35 mm，<0.001）、左下叶（71±22 vs. 48±15 mm，<0.001）和左上叶（86±21 vs. 68±22 mm，<0.001），ILD患者的大传导气道管腔面积大于对照受试者。在ILD患者中，根据气道节段不同，男性的管腔面积（按身高标准化）比女性大17% - 34%（均<0.05）。
