O'Keefe Evan, O'Keefe James H, Tintle Nathan L, Franco W Grant, Westra Jason, Harris William S
Saint Luke's Mid America Heart Institute and University of Missouri-Kansas City, 4401 Wornall Rd, Kansas City, MO 64111.
Fatty Acid Research Institute, 5009 W. 12 st, Ste 5, Sioux Falls, SD 57106.
medRxiv. 2025 Apr 6:2025.04.04.25325263. doi: 10.1101/2025.04.04.25325263.
To determine the relationship between plasma omega-3 levels and incident atrial fibrillation (AF), and the association between fish oil supplement (FOS) use and risk for AF.
Recent studies in UK Biobank concluded that FOS use was associated with increased risk of incident AF. Conversely, a meta-analysis found inverse relationships between blood levels of omega-3 and AF risk. We performed a prospective observational study linking plasma omega-3 levels and reported FOS use with AF risk in UK Biobank. Among UK Biobank participants without prevalent AF, 261 108 had plasma omega-3 levels and 466 169 reported FOS use. The primary outcome was incident AF during follow-up (median 12.7 years). Multivariable-adjusted hazard ratios (HR, 95% confidence intervals, CI) for fatty acids were computed continuously (per inter-quintile range, IQR) and by quintile. Hazard ratios were computed for dichotomous fish oil supplement use.
Plasma omega-3 levels were inversely associated with incident AF (HR per IQR = 0.90, 95% CI 0.86, 0.93; HR=0.87 [0.83, 0.91] in quintile 5 vs quintile 1). Fish oil supplement use was reported by 31% of the cohort and was more common in older individuals. After adjusting for age as a continuous variable, no association was observed between fish oil supplement use and AF risk (HR=1.00; 95% CI 0.97, 1.02).
Higher circulating omega-3 levels were linked to reduced AF risk in UK Biobank. Further, after age was adjusted for as a continuous variable, no association was found between fish oil supplement use and AF.
确定血浆ω-3水平与新发房颤（AF）之间的关系，以及使用鱼油补充剂（FOS）与房颤风险之间的关联。
英国生物银行的近期研究得出结论，使用FOS与新发房颤风险增加有关。相反，一项荟萃分析发现血液中ω-3水平与房颤风险呈负相关。我们在英国生物银行进行了一项前瞻性观察性研究，将血浆ω-3水平和报告的FOS使用情况与房颤风险联系起来。在没有房颤病史的英国生物银行参与者中，261108人有血浆ω-3水平数据，466169人报告了FOS使用情况。主要结局是随访期间（中位时间12.7年）的新发房颤。连续计算脂肪酸的多变量调整风险比（HR，95%置信区间，CI）（每五分位数间距，IQR）并按五分位数计算。计算二分法使用鱼油补充剂的风险比。
血浆ω-3水平与新发房颤呈负相关（每IQR的HR = 0.90，95%CI 0.86，0.93；五分位数5与五分位数1相比，HR = 0.87 [0.83，0.91]）。31%的队列报告使用了鱼油补充剂，在老年人中更常见。将年龄作为连续变量进行调整后，未观察到使用鱼油补充剂与房颤风险之间的关联（HR = 1.00；95%CI 0.97，1.02）。
在英国生物银行中，较高的循环ω-3水平与降低房颤风险有关。此外，将年龄作为连续变量进行调整后，未发现使用鱼油补充剂与房颤之间存在关联。
