Comparative genomic analysis of food-animal-derived and human-derived isolates from markets in Shandong, China.

() is a foodborne pathogen that poses a significant threat to both animal husbandry and public health. In this study, 27 strains were isolated from animal samples and animal-derived food products. Antibiotics resistances among the isolates were phenotypically and genotypically analyzed and Whole genome sequencing (WGS). In combination with the genomes of 141 human-derived strains from public databases, this study conducted comprehensive analyses of antibiotic resistance genes, virulence genes, multilocus sequence typing (MLST), prophage detection, and pan-genome analysis for a total of 168 strains of . Antibiotics resistances among the isolates were phenotypically and genotypically analyzed and found 24 of them (88.9%, 24/27) were identified as multidrug-resistant (MDR). WGS analysis revealed that 13 strains belonged to known sequence types (ST), and the remaining strains represented 10 new STs. By analysis in combination with data of 141 isolates from the database, it was implied that ST221, ST72 and ST370 were present in both animal-derived and human-derived . It is worth noting that 108 out of 168 strains of (64.3%, 108/168) were found to carry prophages, which were found more prevalent in human-derived isolates. Pan-genome and phylogenetic analysis of 168 strains indicated that possesses an open pan-genome with genetic diversity. This study provides genomic insights into from food animals and humans, shedding light on the importance for monitoring the in livestock in China for better public health.