BACKGROUND: For many years, liposuction has remained one of the most-performed cosmetic procedures by plastic surgeons around the world. However, determining the degree of residual skin laxity after evacuation of fat remains a challenge. Renuvion (J-Plasma, Apyx Medical, Clearwater, FL) is a radiofrequency device propelled by helium plasma that generates rapid heating at the subcutaneous layer leading to controlled skin retraction. OBJECTIVES: The authors present the clinical results of their experience with the J-Plasma device in combination with high-definition liposculpture (HDL), while providing some safety recommendations for its use. METHODS: The authors retrospectively collected data from a cohort of patients who underwent HDL in combination with J-Plasma therapy in at least 1 body segment between January 2018 and June 2019 at Dhara Clinic (Bogota, Colombia). Also, 100 patients were randomly selected to complete a satisfaction survey of their results. RESULTS: The authors evaluated 174 consecutive cases: 149 females (85.6%) and 25 males (14.4%). J-Plasma was performed in addition to HDL alone in 96 cases (55.2%), whereas other aesthetic procedures were performed in addition to J-Plasma and HDL in 78 cases (44.8%). They reported 44% of patients as being "very satisfied" and 41% "partially satisfied." CONCLUSIONS: The helium plasma-based device, J-Plasma, has several unique features that enable surgeons to achieve adequate levels of soft-tissue contraction when used in conjunction with liposuction during High-Def body contouring surgery.