Luzhnikov E A, Dagaev V N, Kostomarova L G, Gorin E E
Ter Arkh. 1985;57(5):115-9.
Assay of the clinical course of poisoning with acetic acid, dichloroethane, carbophos, chlorophos, phenobarbital and sodium etaminal in 2538 patients made it possible to define, with the use of the probit analysis, the 25, 50, 75 and 95% concentration thresholds of the lethality in acute poisonings with acetic acid, carbophos and dichloroethane. It was established that under exposure to the toxic substances undergoing different chemical changes in the body, the increase of the lethality risk varied in different age groups. The differences in the structure of outcomes in patients of different age groups formed the basis for making up a classification of the toxicity of the chemical compounds. The differences revealed require a differential approach to the determination of the scope of intensive care of poisonings in terms of the age-associated features.
对2538例乙酸、二氯乙烷、敌百虫、毒死蜱、苯巴比妥和戊巴比妥钠中毒患者的临床病程进行分析，通过概率分析确定了乙酸、敌百虫和二氯乙烷急性中毒致死率的25%、50%、75%和95%浓度阈值。结果表明，在接触体内发生不同化学变化的有毒物质时，不同年龄组的致死风险增加情况有所不同。不同年龄组患者结局结构的差异为化学化合物毒性分类奠定了基础。所揭示的差异要求根据年龄相关特征，对中毒重症监护范围的确定采取差异化方法。
