Bratt G, Törnebohm E, Lockner D, Bergström K
Thromb Haemost. 1985 Apr 22;53(2):208-11.
The pharmacokinetics of a heparin fragment of low molecular weight (LMWH) of 4000-5000 D and unfractioned standard heparin (UFH) have been studied after i.v. injections of different doses and infusions in 8 humans. The heparin activity was significantly higher and the effect on APTT lower after LMWH fragment as compared to UFH in the same doses. The half-life of heparin activity was about 1 hr for UFH and about 2 hr for LMWH. LMWH was found to be eliminated according to first order kinetics and there were no signs of dose dependency.
对8名受试者静脉注射不同剂量并进行输注后，研究了分子量为4000 - 5000道尔顿的低分子量肝素（LMWH）片段和未分级标准肝素（UFH）的药代动力学。与相同剂量的UFH相比，LMWH片段的肝素活性显著更高，而对活化部分凝血活酶时间（APTT）的影响更低。UFH的肝素活性半衰期约为1小时，LMWH约为2小时。发现LMWH按一级动力学消除，且无剂量依赖性迹象。
