Gallino A, Haeberli A, Straub P W
Thromb Res. 1985 Jul 15;39(2):237-44. doi: 10.1016/0049-3848(85)90112-4.
Urinary fpA excretion and fpA in plasma were studied in patients with peripheral artery disease, aortic aneurysm, severe coronary artery disease, acute myocardial infarction and in normal controls. Mean urinary fpA was significantly higher in all groups of patients than in normal controls whose excretion was 1.9 +/- 1.2 micrograms/24 hours (mean +/- SD). We found a good correlation between urinary fpA excretion and plasma fpA (r = 0.68, p less than 0.01, n = 81). The highest levels of urinary fpA were found in 9 patients with aortic aneurysm (11.9 +/- 6.1 micrograms/24 hours). The 10 patients with acute myocardial infarction had also abnormally elevated values (4.3 +/- 1.8 micrograms/24 hours) which were only slightly higher than the levels found in another 10 patients with myocardial infarction receiving subcutaneous heparin in a dosage of 2 X 5000 IU daily (2.9 +/- 1.7 micrograms/24 hours). The 13 patients with peripheral artery disease showed an increase in urinary fpA excretion from 4.0 +/- 1.7 to 10.5 +/- 2.3 micrograms/24 hours after percutaneous angioplasty (p less than 0.001). These data demonstrate that urinary fpA excretion may represent a valid means to detect the cumulative effect of thrombin action on fibrinogen in patients with atherosclerotic vascular disease and after therapeutic intervention.
我们对患有外周动脉疾病、主动脉瘤、严重冠状动脉疾病、急性心肌梗死的患者以及正常对照组的尿纤维蛋白肽A（fpA）排泄量和血浆中的fpA进行了研究。所有患者组的尿fpA平均水平均显著高于正常对照组，正常对照组的排泄量为1.9±1.2微克/24小时（平均值±标准差）。我们发现尿fpA排泄量与血浆fpA之间存在良好的相关性（r = 0.68，p＜0.01，n = 81）。在9例主动脉瘤患者中发现尿fpA水平最高（11.9±6.1微克/24小时）。10例急性心肌梗死患者的值也异常升高（4.3±1.8微克/24小时），仅略高于另外10例每日接受2×5000国际单位皮下肝素治疗的心肌梗死患者的水平（2.9±1.7微克/24小时）。13例外周动脉疾病患者经皮血管成形术后尿fpA排泄量从4.0±1.7微克/24小时增加到10.5±2.3微克/24小时（p＜0.001）。这些数据表明，尿fpA排泄量可能是检测动脉粥样硬化性血管疾病患者以及治疗干预后凝血酶对纤维蛋白原作用的累积效应的有效手段。
