关于日本人胎盘碱性磷酸酶多态性的进一步研究。

A further study on the polymorphism of placental alkaline phosphatase in Japanese.

作者信息

Oya M, Shibata R, Kido A, Komatsu N

出版信息

Tohoku J Exp Med. 1985 Jun;146(2):175-9. doi: 10.1620/tjem.146.175.

DOI:10.1620/tjem.146.175

Abstract

Polymorphism of placental alkaline phosphatase (PL) was investigated in 120 Japanese placentae by means of starch gel electrophoresis and an improved staining method for the isoenzymes using naphthol AS-MX phosphate as substrate instead of beta-naphthyl phosphate. The present method gave more satisfactory results for the detection of the PL bands. Besides five of the six common phenotypes three different uncommon variants were identified. The gene frequencies of PL types were estimated at PL1 = 0.729, PL2 = 0.054, PL3 = 0.200 and PLv = 0.017, which were very similar to those reported in other districts of Japan.

摘要

采用淀粉凝胶电泳法和一种改进的同工酶染色方法（以萘酚 AS - MX 磷酸盐为底物替代β - 萘基磷酸盐），对 120 份日本胎盘进行胎盘碱性磷酸酶（PL）多态性研究。本方法在检测 PL 条带方面给出了更令人满意的结果。除了六种常见表型中的五种外，还鉴定出三种不同的罕见变体。PL 类型的基因频率估计为 PL1 = 0.729、PL2 = 0.054、PL3 = 0.200 和 PLv = 0.017，这与日本其他地区报道的结果非常相似。