Bartolome J, Grignolo A, Bartolome M, Trepanier P, Lerea L, Weigel S, Whitmore W, Michalopoulos G, Kavlock R, Slotkin T
Toxicol Appl Pharmacol. 1985 Aug;80(1):147-54. doi: 10.1016/0041-008x(85)90109-7.
The effects of postnatal methyl mercury exposure on the ontogeny of renal and hepatic responsiveness to trophic stimuli were examined. Increased ornithine decarboxylase (ODC) activity was used as an index of tissue stimulation. In the rat, renal ODC responsiveness to growth hormone, angiotensin, vasopressin, isoproterenol, and serotonin was absent at birth and matured 3 to 4 weeks later. However, pups exposed to methyl mercury showed marked, ODC responses to these same agents as early as 10 to 19 days of postnatal age, accompanied by a significant renal hypertrophy. In contrast to the kidney, the liver of normally developing rats was responsive to trophic factors even in the neonate. In this tissue, there was no consistent effect of neonatal methyl mercury treatment on ODC responses at any developmental stage tested; although absolute liver weights were reduced, liver/body weight ratio was not affected. These results demonstrate that postnatal methyl mercury exposure causes a precocious onset of ODC responses to trophic agents specifically in the kidney. Altered responsiveness may mediate some of the effects of this organomercurial on overall renal development and function.
研究了出生后甲基汞暴露对肾脏和肝脏对营养刺激反应的个体发生的影响。鸟氨酸脱羧酶（ODC）活性增加被用作组织刺激的指标。在大鼠中，肾脏对生长激素、血管紧张素、血管加压素、异丙肾上腺素和血清素的ODC反应在出生时不存在，3至4周后成熟。然而，暴露于甲基汞的幼崽早在出生后10至19天就对这些相同的物质表现出明显的ODC反应，并伴有明显的肾脏肥大。与肾脏不同，正常发育大鼠的肝脏即使在新生儿期也对营养因子有反应。在这个组织中，在任何测试的发育阶段，新生儿甲基汞处理对ODC反应没有一致的影响；尽管绝对肝脏重量减少，但肝脏/体重比不受影响。这些结果表明，出生后甲基汞暴露会导致ODC对营养物质的反应过早出现，特别是在肾脏中。反应性改变可能介导了这种有机汞对整体肾脏发育和功能的一些影响。
